Charles M. Lieber: Liber Research Group: NOT GOOD MAN!!

Found today 04/06/2020

Liber Research Group on harvard.edu WebSite

http://cml.harvard.edu/

Research

Post Docs - (large pool of Chinese students)

Tech & Admin Staff

Former Group Members

more

Sponsored By:

NIH

Office of Naval Research

DARPA

Air Force Office of Scientific Research

MITRE

Publications 1984 - 2019

A treasure trove of 'not good' documents in his work in nanotech, nano-bioelectronics in PDF format

More names than could be listed here

Looks like the groundwork for Transhumanism & NeuralLace is all here. Seems like they could simply inject us with programmed nanotech that would just go to town wiring us up to integrate with the 5G grid. Might be for Cybord type shit…

Pubs For 2019 ALONE!

2019

1. A. Zhang, Y. Zhao, S. You and C.M. Lieber, “Nanowire probes could drive high-resolution brain-machine interfaces,” Nano Today DOI: 10.1016/j.nantod.2019.100821, 9 Dec 2019. [download pdf]

1. M. Sistani, J. Delaforce, R. B. G. Kramer, N. Roch, M. A. Luong, M.I. den Hertog, E. Robin, J. Smoliner, J. Yao, C.M. Lieber, C. Naud, A. Lugstein and O. Buisson, “Highly transparent contacts to the 1D hole gas in ultrascaled Ge/Si core/shell nanowires,” ACS Nano 13, 14145−14151 (2019). [download pdf]

1. M. Tran, K. Shekhar, I.E. Whitney, A. Jacobi, I. Benhar, G. Hong, W. Yan, X. Adiconis, M.E. Arnold, J.M. Lee, J.Z. Levin, D. Lin, C. Wang, C.M. Lieber, A. Regev, Z. He and J.R. Sanes, “Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes,” Neuron 86, 21-24 (2019). [download pdf]

1. S.R. Patel and C.M. Lieber, “Precision electronic medicine in the brain,” Nat. Biotechnol. 37, 1007–1012 (2019). [download pdf]

1. J.M. Lee, G. Hong, D. Lin, T.G. Schuhmann, A.T. Sullivan, R.D. Viveros, H.-G. Park and C.M. Lieber, “Nano-enabled direct contact interfacing of syringe-injectable mesh electronics,” Nano Lett. 19, 5818-5826 (2019). [download pdf] [supplementary info]

1. Y. Zhao, S. You, A. Zhang, J.-H. Lee, J.L. Huang and C.M. Lieber, “Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording,” Nat. Nanotechnol. 14, 783-790 (2019). [download pdf] [supplementary info]

1. R.D. Viveros, T. Zhou, G. Hong, T.-M. Fu, H.Y.G. Lin and C.M. Lieber, “Advanced one- and two-dimensional mesh designs for injectable electronics,” Nano Lett. 19, 4180-4187 (2019). [download pdf]

1. B. Tian and C.M. Lieber, “Nanowired bioelectric interfaces,” Chem. Rev. 119, 9136−9152 (2019). [download pdf]

1. G. Hong and C.M. Lieber, “Novel electrode technologies for neural recordings,” Nat. Rev. Neurosci. 20, 330-345 (2019). [download pdf]

1. X. Yang, T. Zhou, T.J. Zwang, G. Hong, Y. Zhao, R.D. Viveros, T.-M. Fu, T. Gao and C.M. Lieber, “Bioinspired neuron-like electronics,” Nat. Mater. 18, 510–517 (2019). [download pdf] [supplementary info]

1. R. Wang, R.S. Deacon, J. Sun, J. Yao, C.M. Lieber and K. Ishibashi, “Gate tunable hole charge qubit formed in a Ge/Si nanowire double quantum dot coupled to microwave photons,” Nano Lett. 19, 1052-1060 (2019). [download pdf]

meshelectronics.org: More NOT GOOD MAN

Another Charles Lieber WTF site - looks to be the manufacturer of all his twisted ideas.

http://meshelectronics.org/

Found 04/06/2020

NEEDS SCRAPING OF DOCUMENTS ( AS WITH THE LIEBER POST ABOVE ON SAME TOPIC )

Mesh Electronics

Syringe-injectable mesh electronics seamlessly integrate with brain tissue in living animals, opening up exciting opportunities in neuroscience, bioengineering, and medicine. Here we make available to the scientific community protocols and other resources needed to implement this exciting technology. Please contact us with specific questions

Stereotaxic injection

Use a pipette holder to mount the capillary needle containing mesh electronics to a stereotaxic frame, and connect the side outlet of the pipette holder to a syringe pump with capillary tubing.

With the stereotaxic frame, lower the needle to the desired starting coordinates in vivo.

Position a camera to display the top-most I/O pads of the mesh electronics probe in the glass capillary needle.

Set the syringe pump to a low speed (10 mL/h for a 0.4 mm inner diameter needle usually works well) and initiate flow. Slowly increase the flow rate until the probe starts to move within the needle.

Using the stereotaxic frame and the camera focused on the needle as a guide, retract the needle at the same rate as which the mesh electronics probe is being injected. This is done by maintaining the original position of the top I/O pad of the mesh electronics probe within the fixed view of the camera.

Continue to flow solution and retract the needle until the tip of the needle has been withdrawn from the incision. At this point, stop the flow from the syringe pump. The mesh electronics probe should now be spanning from the needle (containing the I/O pads) into the targeted tissue (where the mesh device region has been injected).

I/O interfacing and recording

There are two reported ways to interface to mesh electronics: the "plug-and-play" method and using conductive carbon nanotube-based ink . Both are described below. Note that only one of these methods needs to be implemented to electrically interface to mesh electronics.

References Page

S.R. Patel and C.M. Lieber, “Precision electronic medicine in the brain,” Nat. Biotechnol. DOI: 10.1038/s41587-019-0234-8, 2 September 2019. [Publisher link | PDF]

J.M. Lee, G. Hong, D. Lin, T.G. Schuhmann, A.T. Sullivan, R.D. Viveros, H.-G. Park and C.M. Lieber, “Nano-enabled direct contact interfacing of syringe-injectable mesh electronics” Nano Lett. 19, 5818-5826 (2019) DOI: 10.1021/acs.nanolett.9b03019 [Publisher link | PDF]

Y. Zhao, S. You, A. Zhang, J.-H. Lee, J.L. Huang and C.M. Lieber, “Scalable ultrasmall three-dimensional nanowire transistor probes for intracellular recording,” Nat. Nanotechnol. 14, 783-790 (2019) DOI: 10.1038/s41565-019-0478-y [Publisher link | PDF]

R.D. Viveros, T. Zhou, G. Hong, T.-M. Fu, H.Y.G. Lin and C.M. Lieber, “Advanced one- and two-dimensional mesh designs for injectable electronics,” Nano Lett. 19, 4180-4187 (2019) DOI: 10.1038/s41583-019-0140-6 [Publisher link | PDF]

B. Tian and C.M. Lieber, “Nanowired bioelectric interfaces,” Chem. Rev. 119, 9136−9152 (2019). DOI: 10.1021/acs.chemrev.8b00795. [Publisher link | PDF]

NANO LETTERS: EVEN MORE WTF MAN!!

Found 04/06/2020

http://cml.harvard.edu/assets/acs.nanolett.7b03081-2.pdf

(FYI: TO MUCH IN AFFILIATED REPOS FOR ONE PERSON TO ARCHIVE)

FUCK THESE SICK ASS PEOPLE!!

Syringe-Injectable Electronics with a Plug-and-Play Input/OutputInterface

Thomas G. Schuhmann, Jr.,†Jun Yao,‡Guosong Hong,‡Tian-Ming Fu,‡and Charles M. Lieber*,†,‡

†John A. Paulson School of Engineering and Applied Sciences and‡

Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States*

Supporting Information

ABSTRACT:

Syringe-injectable mesh electronics represent a newparadigm for brain science and neural prosthetics by virtue of thestable seamless integration of the electronics with neural tissues, aconsequence of the macroporous mesh electronics structure with allsize features similar to or less than individual neurons and tissue-likeflexibility. These same properties, however, make input/output (I/O)connection to measurement electronics challenging, and work to-datehas required methods that could be difficult to implement by the lifesciences community. Here we present a new syringe-injectable meshelectronics design with plug-and-play I/O interfacing that is rapid,scalable, and user-friendly to nonexperts. The basic design tapers theultraflexible mesh electronics to a narrow stem that routes all of the device/electrode interconnects to I/O pads that are insertedinto a standard zero insertion force (ZIF) connector. Studies show that the entire plug-and-play mesh electronics can bedelivered through capillary needles with precise targeting using microliter-scale injection volumes similar to the standard meshelectronics design. Electrical characterization of mesh electronics containing platinum (Pt) electrodes and silicon (Si) nanowirefield-effect transistors (NW-FETs) demonstrates the ability to interface arbitrary devices with a contact resistance of only 3Ω.Finally, in vivo injection into mice required only minutes for I/O connection and yielded expected localfield potential (LFP)recordings from a compact head-stage compatible with chronic studies. Our results substantially lower barriers for use by newinvestigators and open the door for increasingly sophisticated and multifunctional mesh electronics designs for both basic andtranslational studies.KEYWORDS:Mesh electronics, neural interface, zero insertion force (ZIF) connection,flatflexible cable (FFC) connector,nanoelectronics interface, nanowirefield-effect transistor

Syringe Injectable Electronics: Precise Targeted Delivery withQuantitative Input/Output Connectivity

http://cml.harvard.edu/assets/NanoLett_2015_15_6979-6984_Hong.pdf

Found 04/06/2020

FUCKING SADISTS ARE RUNNING THE WORLD

Guosong Hong,†Tian-Ming Fu,†Tao Zhou,†Thomas G. Schuhmann,‡Jinlin Huang,†and Charles M. Lieber,†,‡†Department of Chemistry and Chemical Biology and‡John A. Paulson School of Engineering and Applied Science, HarvardUniversity, Cambridge, Massachusetts 02138, United States

Supporting Information

ABSTRACT:

Syringe-injectable mesh electronics with tissue-like mechanical properties and open macroporous structures isan emerging powerful paradigm for mapping and modulatingbrain activity. Indeed, the ultraflexible macroporous structurehas exhibited unprecedented minimal/noninvasiveness and thepromotion of attractive interactions with neurons in chronicstudies. These same structural features also pose newchallenges and opportunities for precise targeted delivery inspecific brain regions and quantitative input/output (I/O)connectivity needed for reliable electrical measurements. Here, we describe new results that address in aflexible manner both ofthese points. First, we have developed a controlled injection approach that maintains the extended mesh structure during the“blind”injection process, while also achieving targeted delivery with ca. 20μm spatial precision. Optical and microcomputedtomography results from injections into tissue-like hydrogel, ex vivo brain tissue, and in vivo brains validate our basic approachand demonstrate its generality. Second, we present a general strategy to achieve up to 100% multichannel I/O connectivity usingan automated conductive ink printing methodology to connect the mesh electronics and aflexibleflat cable, which serves as thestandard“plug-in”interface to measurement electronics. Studies of resistance versus printed line width were used to identifyoptimal conditions, and moreover, frequency-dependent noise measurements show that theflexible printing process yields valuescomparable to commercialflip-chip bonding technology. Our results address two key challenges faced by syringe-injectableelectronics and thereby pave the way for facile in vivo applications of injectable mesh electronics as a general and powerful toolfor long-term mapping and modulation of brain activity in fundamental neuroscience through therapeutic biomedical studies.KEYWORDS:Mesh electronics, ultraflexible brain probe, stereotaxic surgery, controlled injection, dense tissue/gel,high yield input/output connection, conductive ink printing