A large body of clinical evidence demonstrates disease susceptibility and the response to infection and inflammation worsen with elevated iron stores.

Malaria is a second example of an infectious disease that is strongly influenced by host iron status

All known forms of life require iron. Many proteins in living beings contain bound iron ions; those are an important subclass of the metalloproteins. Examples include hemoglobin, ferredoxin, and the cytochromes.

Hemoglobin for example, carries oxygen in the blood by binding one molecule O

2 to the iron atom, forming oxyhemoglobin. In the process, the iron(II) core of hemoglobin loses an electron to become iron(III), while the oxygen molecule is turned into the superoxide anion O−

2.

COV, SARS-COV-2, is impairing hemoglobin oxygen transport?