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Russian doctor offers a new approach to treatment of corona-virus

https://yandex.ru/turbo?text=http%3A%2F%2Fsibkray.ru%2Fnews%2F7%2F933759%2F

Google translated from Russian:

Novosibirsk scientists know how to make coronavirus safe

April 2, 2020

Specialists at the Center for the Prevention of Thrombosis found a way to turn deadly COVID-19 into regular flu. About this discovery Sibkray.ru was told by the head of the Center, candidate of medical sciences Andrei Gromov.

Andrei Alexandrovich, do you really know how to cure a coronavirus?

No, I’m not a virologist and I won’t be able to treat this infection. But we look at the problem from a different perspective. We know how to minimize the effects of a viral infection. After all, people die not from the virus, but from its complications. If you manage to avoid them, then the great and terrible COVID-19 will be no more dangerous than ordinary flu and our immunity will be able to cope with it.

“And what is your confidence based on?” You yourself did not deal with patients with coronavirus?

The fact is that the COVID-19 epidemic has become such a shock for mankind, such a planetary threat, that world science has taken unprecedented measures. Scientists began to exchange information in an emergency. Chinese researchers published detailed protocols on the course of viral infection in major journals. And I, as a specialist who develops technologies for the diagnosis and treatment of thrombosis, saw a weak spot in the therapy used today. The fact is that the whole world treats the virus, that is, the pathogen itself is trying to destroy. And we decided that until the anti-virus remedy was found, we should concentrate our efforts on preventing consequences and complications.

Now in the world against COVID-19, two methods of treatment are used. The first is antiviral drugs, Chinese doctors mainly used ribavirin. The second is powerful anti-inflammatory substances designed to prevent the development of pneumonia. Those that are really effective are heavy anti-malarial drugs, such as Chloroquine, Hydroxychloroquine. A lot has been written about them. But, as experience shows, these drugs are not enough.

“What do you suggest?”

And we found a weak spot in this infection . As you know, it affects one organ - these are the lungs. There we have the main "battle". Therefore, it was the lungs that we decided to protect - to prevent pathology from developing in them. After all, pneumonia does not begin on the first day. The infection spreads quite slowly. At first it “occupies” the nasopharynx, then gradually “crawls” to the lungs. Therefore, doctors have the opportunity to buy time.

In Russia, the situation is not as serious as it was in China. About 23% of patients have an asymptomatic infection in our country, they have a small viral load, and their immunity copes with the disease on their own. In 63-65% of patients, a viral infection of the type of influenza or parainfluenza develops. And only in 14% everything flows into pneumonia. This is the data of Rospotrebnadzor. Up to a third of patients with complications in the form of pneumonia do not survive. And they die precisely from pneumonia. Moreover, it is disastrous. Even those recovering develop adhesions. That is, the lungs are pulled together by a scar of connective tissue, and a person remains with respiratory failure for life - in fact, becomes an invalid. So, if you stop the development of pneumonia, then the virus can cope with the virus itself.

“But doesn't our medicine know how to treat pneumonia?”

This is not about ordinary pneumonia. Here is the thing. COVID-19 is a smart virus. Once in the lungs, he is waiting for an immune response. And immunity throws all its defenses there, these are white blood cells, and special proteins, and NK cells, and T-lymphocytes, and macrophages … They act like artillery shells or grenades. There is an explosive reaction. That is, they destroy the virus, but also damage the surrounding tissue. And lung tissue - it is all riddled with blood vessels. And a side effect of this battle is rapid pulmonary edema. Breathing begins to break. Moreover, the more our defenders “try”, the more they throw out inflammatory proteins, the more their native cells are damaged.

It turns out, the more actively the body fights, the sooner it loses?

In fact of the matter! And watch what happens. These "explosives" that immunity cells emit for our protection, they damage the walls of blood vessels. And then blood plasma penetrates into the lungs, into the respiratory vesicles (alveoli). It contains fibrinogen - a large fibrous protein, it is needed in order to close the damage to blood vessels. That is, in principle, fibrinogen protects us from bleeding. But in this case, he begins to work against the body.

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A cunning virus wraps the situation in its favor and uses fibrinogen for its own protection. He builds around himself a kind of ramparts, walls, trenches, dugouts, so that he can no longer get close to him. But another thing is worse - in the lungs, thus, numerous microthrombi are formed.

That is, the virus reverses our immunity against ourselves?

That's it. In fact, he uses our defense system for his own purposes. This is the trick. Not without reason, everyone notes that this is a very smart virus, it specifically causes such a blast wave in the human body - it provokes us. He initially “knows” this mechanism and expects to use it in order to entrench himself, fence himself and protect himself from the body by blood clots.

As a result, blood clots flood the lung, squeeze it from all sides - and as a result, we have all these difficult cases, including deaths. If we can stop the process of thrombosis, the problem will be solved - the virus will lose its lethality.

But surely this mechanism is known not only to you?

Of course not. We are not the only ones in the world so smart. But there is one point. I am a specialist in thrombosis. The doctors who are now struggling with COVID-19 have no experience dissolving large blood clots, and I have 30 years of experience. I know how this works, I myself dissolved pulmonary thromboembolism, and these are very heavy blood clots, equal in mortality to a heart attack. And I understand what can be done in case of coronavirus pneumonia.

So what?

Here I will not open America. There are well-known remedies. Firstly, these are anticoagulants - they interfere with blood coagulation, for example, heparins. And secondly, thrombolytics - they dissolve blood clots. (By the way, I note in parentheses: low molecular weight heparins are produced in Milan. And I do not know why Italian doctors do not use them.)

But the most important thing is the time to start treatment. Now all over the world, patients are being treated when it is too late - pneumonia is in full swing, blood clots have already developed, a person is in serious condition. We suggest doing this much earlier. Since the virus gives us time, we need to start treatment before it comes to pneumonia. Introduce heparins to those who have just had shortness of breath - moderate patients. And, of course, to everyone who is at risk, who are over 60, who have chronic diseases — cardiovascular, diabetes, oncology … This, you can say, is our Novosibirsk exclusive, our know-how.

But there is another local exclusive. The fact is that the Americans, as far as I know, also had the idea that blood clots could be dissolved. And even the other day they decided to try this idea. But the problem is that their thrombolytic is very expensive and it is not possible to use it massively, only on the most severe patients. And such patients, as we said, are often too late to treat. So, about the exclusive. In Novosibirsk, they produce a drug that is much cheaper, has no side effects and can be massively used for treatment in such situations. This is Trombovazim, it is well known to specialists.

Humanity is not yet able to defeat COVID-19. Until specialized antiviral drugs and a vaccine appear, he will infect us. But what we can and offer to do today is to minimize mortality. Stop the disaster. Save the lives of thousands of people who die from the effects of coronavirus every day. It is quite real. And then the infection will go into the category of habitual respiratory diseases, hospitals will be unloaded, people will perceive COVID-19 as a normal flu, which, of course, is not very pleasant to hurt, but not mortally dangerous.

For reference: Andrey Gromov , Director of the Center for the Prevention of Thrombosis, Ph.D., Senior Researcher at the Laboratory of Clinical Biochemical and Hormonal Studies of Therapeutic Diseases, Research Institute of Therapy and Preventive Medicine, author and co-author of seven textbooks and monographs, as well as more than 250 printed scientific papers, speaker of many international and European medical congresses.

Author: Nina Zheludkova