Anonymous ID: 2a4300 April 14, 2020, 11:41 a.m. No.8791255   🗄️.is 🔗kun   >>1265 >>1307 >>1350

Q is this correct?

 

"Chloroquine analogues have been credited with saving the lives of thousands of patients with malaria. Since the first use of chloroquine analogues nearly a century ago, their effectiveness has been increasingly recognized in nearly all major branches of medicine, including immunology, oncology, haematology, dermatology, cardiology and severe infectious diseases such as AIDS and SARS. Although these drugs are not FDA approved for several therapies, rheumatologists, dermatologists and other professionals have recognized their effectiveness for various pathologies in their specialities. To date, chloroquine analogues have established roles in the treatment of SLE, RA, osteoarthritis, cancers and various skin diseases (e.g. lichen planus and Sjögren's syndrome). There are also currently many clinical trials studying the effects of chloroquine analogues in various diseases, such as malignant neoplasms of the lung, breast, prostate, pancreas and colon, melanoma, renal cell carcinoma, multiple myeloma, influenza, HIV infection, and the metabolic syndrome (Table 5). To investigate the roles of these analogues in a wide variety of diseases, a number of molecular modifications, such as the prodrug131 and metabolomic approaches,132 have been used with the aims of improving their pharmacokinetic and pharmacodynamic properties, reducing undesirable side effects, costs and drug sensitivities. However, the exact mechanisms of action of the analogues and their effectiveness in these diseases remain to be demonstrated. Despite their benefits and their current use in >70 countries, chloroquine analogues remain unavailable for clinical use to treat patients in Japan due to a series of lawsuits as a result of the retinal toxicity of chloroquine in the 1970s. However, because of their use as the standard of care worldwide, clinical trials of hydroxychloroquine for SLE in Japan have recently been started.133,134 Our understanding of the history of chloroquine analogues suggests that the appropriate use of an efficacious therapy will soon lead to an era of improvement of patient care, survival and quality of life for many patients."

 

https://academic.oup.com/jac/article/70/6/1608/728687#12820331