Anonymous ID: 39d03e April 17, 2020, 9:51 a.m. No.8825827   🗄️.is 🔗kun   >>5865

>>8825556 MMV

 

The case study presented here demonstrates that MMV is a ubiquitous threat to CHO (Chinese hamster ovary) cell-based production of biologic drugs and that animal-free media components can be a contamination source. Compounding the risk posed by MMV, the contamination may be "silent," with no impact on cell viability and product titers. Furthermore, contamination may not be detected using in vitro virus assays, and assays based on PCR (polymerase chain reaction) are required for reliable detection.