>>8828374
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Chloroquine: Novel uses & manifestations
''Division of Physiology, Faculty of Health, Birmingham City University & *University of Leeds, Faculty of
Medicine & Health, St. James’ University Hospital, Cancer Research Building, Leeds, UK''
Chloroquine (CHQ) is a cheap, relatively well tolerated drug initially developed for the treatment
of malaria in the 1930s. CHQ has, however, since accrued a plethora of uses in the treatment and
amelioration of several other diseases and conditions because of its lysosomotropic properties. It
also has characteristic physiological and systemic effects. This review gives an overview of the
history and pharmacology of CHQ, and progresses to consider some of the mechanisms that may
underlie its biochemical and physiological effects. Additionally, an overview of some of the novel
uses of CHQ in the treatment of viral infections and cancer are presented. The antimalarial
mechanisms of CHQ were not discussed in this review. The message is that CHQ, despite its welldocumented toxicity and adverse side effects may have important future uses that are associated
with its lysosomotropic and immunomodulatory mechanisms. The possibility exists therefore that
CHQ might be re-introduced into regular malaria treatment.
The 12 page article from a medical journal is attached as PDF