CHLOROQUINE AND 2-DEXYGLUCOSE CURE PROSTATE CANCER IN MICE 2016

https://www.sciencedirect.com/science/article/pii/S2352396416301098

Mechanism-driven co-targeting hexokinase 2 (HK2)-mediated Warburg effect with 2-deoxyglucose (2-DG) and ULK1-dependent autophagy with chloroquine (CQ) selectively kills cancer cells through intrinsic apoptosis to cause tumor regression in xenograft, leads to a near-complete tumor suppression and remarkably extends survival in Pten −/p53-deficiency-driven CRPC mouse model.