The world is rushing towards a COVID19 vaccine. A vaccine against the new corona virus promises protection as well as freedom of movement. However, the COVID19 vaccine could be worse than the disease. This is not just an academic discussion. There are risks and you should be aware of them.

Could a vaccine be worse than the disease?

Vaccines have saved millions from many different diseases since 1797 when Edward Jenner developed the first vaccine for smallpox. Many people consider the benefits of vaccines to outweigh their risks. However, could a new COVID-19 vaccine impose more risks than benefits?

Some of new the vaccine technologies have long names that may elicit a “Whatever” response. To understand the potential danger of these new technologies, you do not need a degree in immunology, genetics, or vaccine production. Here are the main points—

1) New vaccines technologies can prevent plagues like the new COVID-19 or they could be a mad scientist’s dream come true.

2) Some vaccine technologies can be used for either vaccines or gene therapy. In the wrong hands these gene therapies/vaccines could reprogram many body functions. For example, they could shut down the thyroid’s ability to produce hormones, forcing you to purchase thyroid medication like someone who had their thyroid gland removed due to cancer. They could shut down the body’s ability to produce blood clotting factors, forcing people to either buy clotting factors or die. Other possibilities run into the thousands.

3) Gene suppression or gene silencing can vary from hours to weeks. Some gene therapies are being developed to knock out specific gene for the rest of a person’s life

If you think the statements are conspiracy theories, I ask you to be open-minded before dismissing this as “Whatever.”

If any this concerns you, contact your elected officials and demand that the Food and Drug Administration does not approve new COVID19 vaccines unless there is robust independent surveillance and fail-safe procedures to prevent malicious use of gene therapies/vaccines. You can contact your Senator at https://contactsenators.com/ . You can contact your representative at https://www.house.gov/representatives . You can contact President Trump and Vice President Pence at https://www.whitehouse.gov/contact/

Who is against and who is in favor of vaccines?

Robert Kennedy Jr. (son of Robert F. Kennedy, nephew of former president John F. Kennedy is an attorney who strongly opposes vaccination. Kennedy goes further to allege the vaccine manufactures are corrupt felons and recommends that we should not trust them. He also points out the vaccine companies cannot be sued so it is harder to use lawsuits to discover any wrongdoing or sloppiness. https://www.youtube.com/watch?v=zyxEo2kqo08

Dr. Ron Paul—a physician and former U.S. Representative—believes “People ‘Should Be Leery About’ a Coronavirus Vaccine .” (http://www.ronpaulinstitute.org/archives/peace-and-prosperity/2020/april/14/ron-paul-people-should-be-leery-about-a-coronavirus-vaccine/

Bill and Melinda Gates strongly advocate for vaccinations. (https://www.gatesfoundation.org/What-We-Do/Global-Health/Vaccine-Development-and-Surveillance )

“Bill Gates in 2010 expressed the hope that vaccines along with “family planning” could bring population growth to nearer to zero.” Gates, B. (2010) Bill Gates: Innovating to Zero! http://www.ted.com/talks/bill_gates

“HCG Found in WHO Tetanus Vaccine in Kenya Raises Concern in the Developing World” In 1993, WHO announced a “birth-control vaccine” for “family planning”. Published research shows that by 1976 WHO researchers had conjugated tetanus toxoid (TT) with human chorionic gonadotropin (hCG) producing a “birth-control” vaccine. Conjugating TT with hCG causes pregnancy hormones to be attacked by the immune system. Expected results are abortions in females already pregnant and/or infertility in recipients not yet impregnated. Repeated inoculations prolong infertility. Currently WHO researchers are working on more potent anti-fertility vaccines using recombinant DNA. WHO publications show a long-range purpose to reduce population growth in unstable “less developed countries”. By November 1993 Catholic publications appeared saying an abortifacient vaccine was being used as a tetanus prophylactic…. mothers-to-be were misled into accepting an anti-fertility vaccine in the hope of protecting their future children from neonatal tetanus, the “do-no-harm caveat” was violated. In receiving up to five antifertility injections any mothers-to-be would almost certainly be robbed of the very children they were trying to protect from neonatal tetanus.” https://www.researchgate.net/publication/320641479_HCG_Found_in_WHO_Tetanus_Vaccine_in_Kenya_Raises_Concern_in_the_Developing_World

Bill Gates has been donating a lot of money to development of a new Coronavirus Vaccine. Bill And Melinda Gates Donate $100 Million To Coronavirus Vaccine Research And Treatment” https://www.forbes.com/sites/lisettevoytko/2020/02/05/bill-and-melinda-gates-donate-100-million-to-coronavirus-vaccine-research/ And, “Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines | Bill & Melinda Gates Foundation” https://www.gatesfoundation.org/Media-Center/Press-Releases/2010/01/Bill-and-Melinda-Gates-Pledge-$10-Billion-in-Call-for-Decade-of-Vaccines

Others are calling for development of new vaccines. George Soros’ Open Society Institute is calling for “development of new tools to combat TB, including a more effective vaccine with longer-lasting protection than BCG, the current vaccine.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566717/pdf/11799456.pdf

People at risk of COVID19 complications need a vaccine to protect them from COVID19. However, we need a safe vaccine that cannot be used as a Trojan Horse. Robust independent surveillance from manufacturing to point of use are necessary to prevent malicious activity. These could include methods to detect extraneous RNA and DNA. Other methods of verification and fail-safe procedures could also be included to prevent malicious activity.

If any this concerns you, contact your elected officials and demand that the Food and Drug Administration does not approve new COVID19 vaccines unless there is robust independent surveillance and fail-safe procedures to prevent malicious use of gene therapies/vaccines. You can contact your Senator at https://contactsenators.com/ . You can contact your representative at https://www.house.gov/representatives . You can contact President Trump and Vice President Pence at https://www.whitehouse.gov/contact/

References:

1) Andrew J. Geall, Ayush Verma, Gillis R. Otten, Christine A. Shaw, Armin Hekele, Kaustuv Banerjee, Yen Cu, Clayton W. Beard, Luis A. Brito, Thomas Krucker, Derek T. O’Hagan, Manmohan Singh, Peter W. Mason, Nicholas M. Valiante, Philip R. Dormitzer, Susan W. Barnett, Rino Rappuoli, Jeffrey B. Ulmer, and Christian W. Mandl, Nonviral delivery of self-amplifying RNA vaccines, Proc Natl Acad Sci U S A. 2012 Sep 4; 109(36): 14604–14609. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3437863/#r4 , Published online 2012 Aug 20. doi: 10.1073/pnas.1209367109

2) Pedro Berraondo, Paolo G V Martini, Matias A Avila, Antonio Fontanellas, Messenger RNA therapy for rare genetic metabolic diseases, MJ Publishing Group, volume 68, Issue 7,https://gut.bmj.com/content/68/7/1323.long

3) Susanne Rauch, Edith Jasny, Kim E. Schmidt and Benjamin Petsch, New Vaccine Technologies to Combat Outbreak Situations, (Front. Immunol., 19 September 2018 https://doi.org/10.3389/fimmu.2018.01963 https://www.frontiersin.org/articles/10.3389/fimmu.2018.01963/full provides an thorough explanation of various different vaccine technologies along with the respective advantages and disadvantages. The article ends with a recommendation for development of new vaccine technology using self-amplifying messenger RNA or Self-Amplifying mRNA vaccine.

4) Brito LA, Kommareddy S, Maione D, Uematsu Y, Giovani C, Berlanda Scorza F, Otten GR, Yu D, Mandl CW, Mason PW, Dormitzer PR, Ulmer JB, Geall AJ,Self-amplifying mRNA vaccines, Adv Genet. 2015;89:179-233. doi: 0.1016/bs.adgen.2014.10.005. Epub 2014 Dec 4. https://www.ncbi.nlm.nih.gov/pubmed/25620012

5) Abby Olena, Newer Vaccine Technologies Deployed to Develop COVID-19 Shot, Feb 21, 2020, https://www.the-scientist.com/news-opinion/newer-vaccine-technologies-deployed-to-develop-covid-19-shot-67152

6) U.S. Department of Health and Human Services, HHS Accelerates Clinical Trials, Prepares for Manufacturing of COVID-19 Vaccines, March 30, 2020, https://www.hhs.gov/about/news/2020/03/30/hhs-accelerates-clinical-trials-prepares-manufacturing-covid-19-vaccines.html

7) Wolff JA, Malone RW, Williams P, Chong W, Acsadi G, Jani A, Felgner PL, Direct gene transfer into mouse muscle in vivo Science 1990 Mar 23;247(4949 Pt 1):1465-8. https://www.ncbi.nlm.nih.gov/pubmed/1690918

8) Yen Cu, Kate E. Broderick, Kaustuv Banerjee, Julie Hickman, Gillis Otten, Susan Barnett, Gleb Kichaev, Niranjan Y. Sardesai, Jeffrey B. Ulmer, and Andrew Geall, Enhanced Delivery and Potency of Self-Amplifying mRNA Vaccines by Electroporation in Situ Vaccines (Basel). 2013 Sep; 1(3): 367–383. Published online 2013 Aug 22. doi: 10.3390/vaccines1030367 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4494232/

9) Alicia Rodríguez-Gascón, Ana del Pozo-Rodríguez, and María Ángeles Solinís, Development of nucleic acid vaccines: use of self-amplifying RNA in lipid nanoparticles Int J Nanomedicine. 2014; 9: 1833–1843. Published online 2014 Apr 10. doi: 10.2147/IJN.S39810 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3986288/ (In Europe, all mRNA-based therapies fall under the scope of the regulation for advanced therapy medicinal products.27,28 “In Europe, all mRNA-based therapies fall under the scope of the regulation for advanced therapy medicinal products.27,28 gene therapy medicinal product is an active substance which contains or consists of a recombinant nucleic acid used in or administered to human beings”; therefore, mRNA is categorized as gene therapy. In contrast, in the USA, mRNA-based vaccination therapies are not considered as gene therapy.”)

10) Kreiter S, Diken M, Selmi A, Türeci Ö, Sahin U., Tumor vaccination using messenger RNA: prospects of a future therapy, Curr Opin Immunol. 2011 Jun;23(3):399-406. doi: 10.1016/j.coi.2011.03.007. Epub 2011 Apr 13., https://www.ncbi.nlm.nih.gov/pubmed/21497074

11) Yanez Arteta M, Kjellman T, Bartesaghi S, Wallin S, Wu X, Kvist AJ, Dabkowska A, Székely N, Radulescu A, Bergenholtz J, Lindfors L. Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles. Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3351-E3360. doi: 10.1073/pnas.1720542115. Epub 2018 Mar 27. https://www.ncbi.nlm.nih.gov/pubmed/29588418

12) Andreas Thess, Stefanie Grund, Barbara L Mui, Michael J Hope, Patrick Baumhof, Mariola Fotin-Mleczek, and Thomas Schlake, Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals, Mol Ther. 2015 Sep; 23(9): 1456–1464. Published online 2015 Jun 30. Prepublished online 2015 Jun 8. doi: 10.1038/mt.2015.103 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817881/

13) World Health Organization, Bulletin of the World Health Organization, 2001,79(12), https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2566717/pdf/11799456.pdf

14) Zeljka Trepotec, Eva Lichtenegger, Christian Plank, Manish K. Aneja, Carsten Rudolph, Delivery of mRNA Therapeutics for the Treatment of Hepatic Diseases. Review| Volume 27, ISSUE 4, p 794-802, April 10, 2019 https://www.cell.com/molecular-therapy-family/molecular-therapy/fulltext/S1525-0016(18)30616-6

15) Xiangjun Tang, Shenqi Zhang, Rui Fu, Li Zhang, Kuanming Huang, Hao Peng, Longjun Dai, and Qianxue Chen, Therapeutic Prospects of mRNA-Based Gene Therapy for Glioblastoma, Front Oncol. 2019; 9: 1208. Published online 2019 Nov 8. doi: 10.3389/fonc.2019.01208 , https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857656/#B25

16) Annette B.Vogel, LauraLambert, EkaterinaKinnear, DavidBusse, StephanieErbar, Kerstin C.Reuter, LenaWicke, MarioPerkovic, TimBeissert, HeinrichHaas, Stephen T.Reece, UgurSahin, John S.Tregoning, Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses, Molecular Therapy , Volume 26, Issue 2, 7 February 2018, Pages 446-455, https://doi.org/10.1016/j.ymthe.2017.11.017 , https://www.sciencedirect.com/science/article/pii/S1525001617305944

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Silly Shill