https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509173/

Anti-infective Properties of the Golden Spice Curcumin

Turmeric (Curcuma longa L.) belongs to the family of ginger (Zingiberaceae) and natively grows in India and Southeast Asia. The plants rhizomes contain several secondary metabolites including curcuminoids, sesquiterpenes, and steroids (Omosa et al., 2017); with the curcuminoid curcumin being the principal component of the yellow pigment and the major bioactive substance.

Antiviral Activities of Curcumin

Due to the lack of preventive and therapeutic options for many viral infections, numerous studies have been conducted to investigate the antiviral potential of natural compounds. Accordingly, antiviral effects haven been shown, e.g., for components of green tea (as reviewed, e.g., Steinmann et al., 2013), cinnamon (Connell et al., 2016) and many herbs. For curcumin, an antiviral activity was observed against several different viruses including hepatitis viruses, influenza viruses and emerging arboviruses like the Zika virus (ZIKV) or chikungunya virus (CHIKV). Interestingly, it has also been reported that the molecule inhibits human immunodeficiency virus (HIV), herpes simplex virus 2 (HSV-2) and human papillomavirus (HPV), indicating that curcumin reduces the spread of sexually transmitted diseases. In this section and in Table 1 we will summarize the current understanding of the antiviral aspects of curcumin and possible mechanisms underlying its inhibitory effects.

(Youtube is banning the mention of turmeric and vitamin c as treatment for covid 19)

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Table 1

Antiviral activity of curcumin against several different viruses.

Virus Family Antiviral activity References

CHIKV Togaviridae Entry inhibitor Rhein et al., 2016

DENV Flaviviridae Entry inhibitor

Particle production inhibition Chen et al., 2013

Padilla-S et al., 2014

HBV Hepadnaviridae Replication inhibitor

cccDNA inhibitor Kim et al., 2009, 2011;

Rechtman et al., 2010

Wei et al., 2017

HCV Flaviviridae Entry inhibitor Anggakusuma et al., 2014

HIV Retroviridae Protease inhibitor

Integrase inhibitor

Tat protein inhibitor Sui et al., 1993

Mazumder et al., 1995

Barthelemy et al., 1998; Balasubramanyam et al., 2004; Ali and Banerjea, 2016

HPV Papilomaviridae Gene expression inhibition Maher et al., 2011; Mishra et al., 2015

HSV Herpesviridae Gene expression inhibition Kutluay et al., 2008

IAV Orthomyxoviridae Entry inhibitor Chen et al., 2010; Ou et al., 2013

JEV Flaviviridae Entry inhibitor

Particle production inhibition Chen et al., 2013

Padilla-S et al., 2014

MNV Caliciviridae Entry inhibitor Yang M. et al., 2016

RSV Pneumoviridae Entry inhibitor

Replication and budding inhibition Yang X.X. et al., 2016;

Yang et al., 2017

Obata et al., 2013

RVFV Phenuiviridae Replication inhibitor Narayanan et al., 2012

ZIKV Flaviviridae Entry inhibitor Mounce et al., 2017

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4022204/

A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

Curcuma longa L. (Zingiberaceae family) and its polyphenolic compound curcumin have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for curcumin and rhizome extract of C. longa against different bacteria, viruses, fungi, and parasites have been reported. The promising results for antimicrobial activity of curcumin made it a good candidate to enhance the inhibitory effect of existing antimicrobial agents through synergism. Indeed, different investigations have been done to increase the antimicrobial activity of curcumin, including synthesis of different chemical derivatives to increase its water solubility as well ass cell up take of curcumin. This review aims to summarize previous antimicrobial studies of curcumin towards its application in the future studies as a natural antimicrobial agent.

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136164/

Recent developments in anti-severe acute respiratory syndrome coronavirus chemotherapy

https://www.ncbi.nlm.nih.gov/pubmed/17663539

Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus.

Abstract

In this study, 221 phytocompounds were evaluated for activity against anti-severe acute respiratory syndrome associated coronavirus (SARS-CoV) activities using a cell-based assay measuring SARS-CoV-induced cytopathogenic effect on Vero E6 cells. Ten diterpenoids (1-10), two sesquiterpenoids (11 and 12), two triterpenoids (13 and 14), five lignoids (15-19), curcumin (20), and reference controls niclosamide (21) and valinomycin (22) were potent inhibitors at concentrations between 3.3 and 10 microM. The concentrations of the 22 compounds to inhibit 50% of Vero E6 cell proliferation (CC50) and viral replication (EC50) were measured. The selective index values (SI = CC50/EC50) of the most potent compounds 1, 5, 6, 8, 14, and 16 were 58, >510, 111, 193, 180, and >667, respectively. Betulinic acid (13) and savinin (16) were competitive inhibitors of SARS-CoV 3CL protease with Ki values = 8.2 +/- 0.7 and 9.1 +/- 2.4 microM, respectively. Our findings suggest that specific abietane-type diterpenoids and lignoids exhibit strong anti-SARS-CoV effects.

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These were mostly black Vietnam vets with diabetes.

One of the things that hydroxychloroquine is good at is getting it early, preventing, nipping it in the bud. As a preventative, you don't want to be taking zpack. But when it gets far along, you certainly do want zpack.

I don't think this is the cannibal group.

>>8879455

many small businesses sell some important things.

And since 1) there are a lot more people with covid than they thought and 2) covid isn't as severe as they thought, then why not just say "fuck it" and open everything back up.

A) remember to tell nursing home workers to wash their hands

B) keep K-12 closed. Opening it back up creates the illusion that it serves some purpose.