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Does military’s secret biodefense lab hold a key to future coronavirus treatment?
Though often omitted from public conversations about pandemic solutions, the U.S. military has a huge stake in fighting deadly infectious diseases and quietly has been researching novel treatments for years at its secretive biodefense lab at Fort Detrick.
The reasons are mission obvious. With soldiers deployed in exotic locations around the world where novel viruses like Ebola, Zika or bird and swine flus can strike with lighting speed and alarming fatality, the Pentagon wants to make sure it has treatments to keep its forces from being disabled
It’s from that body of research that an intriguing potential remedy, an organic extract, has emerged. And of all sources, it comes from the common but toxic flowering plant oleander.
Dr. John Dye, chief of viral immunology at the USAMRIID lab at Fort Detrick, confirmed to Just the News that his team began testing the extract known as oleandrin a few years ago and found it was effective in fighting the Ebola and Marburg viruses. The Army lab is now ramping up a rapid plan to test oleandrin against COVID-19.
“We found that at non-toxic concentrations, oleandrin was efficacious at slowing and halting viral growth in tissue culture assays” for the Ebola and Marburg viruses, Dye said in emailed answers to questions.
Because those viruses are enveloped, just like COVID-19, the lab is pressing ahead to do similar tests on the theory that the extract may have similar effects on the coronavirus at the center of today’s pandemic, he said.
“We are finalizing arrangements to test oleandrin in our tissue culture assays for COVID-19 virus,” he said.
Oleandrin has been a rising star in the biomedical world the last few years, with some clinical trials now showing it has helped several types of cancer patients improve. Because it is natural and appears to work in low, non-toxic doses and has a track record in the cancer world, it could have appeal should Dye’s lab find it works on the coronavirus.
In fact, Dye said, it was oleandrin’s success in cancer research that first put it on his team’s radar.
“A scientist moved from MD Anderson Cancer Center in Houston to my group, and he provided the introduction for the oleandrin team,” he explained. “We were encouraged by the data that had been generated against other infectious viruses and decided to pursue testing with the filoviruses, Ebola and Marburg.”
Fort Detrick’s research was presented at a 2017 medical conference that did not generate much media attention but provided a strong endorsement that oleandrin appeared to have strong potential for fighting enveloped viruses, which use disguises to infect the body without detection. Dye and a fellow researcher from Fort Detrick joined the findings along with scientists for Phoenix Biotechnology, the San Antonio, Texas-based company that has developed the extract.
Oleandrin “fully inhibited” the Marburg and Ebola viruses in petri dishes, suggesting the natural compound has “broad spectrum efficacy” and may also have “antiviral efficacy against other enveloped viruses,” the researchers' presentation declared in 2017.
It was that data that gave Dye’s lab an interest in testing oleandrin against COVID-19 now. If the in-vitro tests show it works, the next step would be human testing in clinical trials.
Andrew Whitney, executive chairman of Phoenix Biotechnology, told Just the News he is excited that Dye’s lab is beginning testing against the coronavirus and said a separate lab has already done extensive testing in recent weeks and preliminarily found oleandrin is effective against COVID-19.
“One leading U.S. institution has already reported remarkable efficacy of our compound against COVID-19, having completed multiple lab studies over the past month. We will soon make the details of that public,” he said.
Because oleandrin already has wide user in cancer trials and comes from a plentiful flower product, it has advantages in getting to market more quickly should Fort Detrick’s tests and then subsequent clinical trials find it is effective and safe, he added.
“Of great importance is the fact that our solution is based on an Active Principal Ingredient that is 100% natural, made entirely in America, and our solution is available in significant scale, now,” he said.
https://justthenews.com/politics-policy/coronavirus/does-militarys-secret-biodefense-lab-hold-key-future-coronavirus
https://justthenews.com/sites/default/files/2020-04/Stonier%20poster%20%281%29.pdf
Democrats plan to censure lawmaker who credited Trump for COVID-19 recovery
Detroit Democrats plan to vote Saturday to censure and bar any future endorsements of a Democratic lawmaker who credited President Donald Trump with advocating for the drug that she said cured her of COVID-19.
State Rep. Karen Whitsett, D-Detroit, broke protocol by meeting with President Donald Trump and Vice President Mike Pence during an April 14 meeting of COVID-19 survivors, during which she credited hydroxychloroquine for saving her life.
“Thank you for everything that you have done,” Whitsett told Trump at the meeting. “I did not know that saying thank you had a political line. … I’m telling my story and my truth, and this how I feel and these are my words.”
The meeting and other comments Whitsett made prior to and during the coronavirus pandemic have landed her in hot water with the 13th Congressional District Democratic Party Organization.
The group, as first reported by Gongwer News Service, plans to vote Saturday on a resolution to censure Whitsett, a first-term lawmaker representing the 9th Michigan House District.
The admonition means she will not get the group’s endorsement for this year nor will she be able to engage in the group’s activities for the next two election cycles.
“At the end of the day, we have political systems,” said Jonathan Kinloch, chairman of the organization. “We have political parties, and political parties exist for a reason."
“They do not belong to themselves,” Kinloch said of endorsed candidates and elected officials. “They belong to the members and precinct delegates of the Democratic Party.”
Whitsett could not immediately be reached for comment.
Kinloch said the party’s problems with Whitsett date back to comments she made about House Democratic leadership and the Democratic legislative caucus at large.
In February, Whisett told WWJ-AM (950) that House Democratic Leader Christine Greig of Farmington Hills was a racist because she wouldn’t consider an urban agenda for the caucus. Greig also pulled Whitsett’s communications staff because of an unfavorable vote on an early rendition of the no-fault auto reform bill, Whitsett said.
A later version of the no-fault auto reform legislation received overwhelming support in the state House and was signed into law by Democratic Gov. Gretchen Whitmer.
The resolution Detroit Democrats will vote on notes she has "misrepresented the needs and priorities" of Democratic leadership to the president and public.
The resolution also notes she's participated in events with the Republican Women's Federation of Michigan to express gratitude to the president.
Whitsett, the resolution said, "has repeatedly and publicly praised the president's delayed and misguided COVID-19 response efforts in contradiction with the scientifically based and action-oriented response" from Michigan's Democratic leadership, "endangering the health, safety and welfare of her constituents, the city of Detroit and the state of Michigan."
Michigan State Medical Society President Dr. Mohammed Arsiwala prescribed hydroxychloroquine and an antibiotic for Whitsett after she visited one of his Michigan Urgent Care clinics in Wyandotte. She had symptoms of COVID-19 and an underlying condition, he told The Detroit News.
The Trump administration has deployed about 28 million doses of hydroxychloroquine from the federal government’s Strategic National Stockpile. While hydroxychloroquine is effective at treating lupus and rheumatoid arthritis, the drug can be dangerous for people with certain heart conditions.
On Sunday, after Whitsett continued to make negative comments about the party and Whitmer, the 13th Congressional Democratic group asked her to come in for a “screening” of candidates for her house district. Whitsett refused, Kinloch said.
“Don’t play with us,” Kinloch said. “This is very serious when we ask to have a conversation with you and you choose not to.
“We’re not going to accept that. How they handle you in Lansing as far as the Democratic caucus that’s on them. But how we handle you back at home, that’s on us.”
https://www.detroitnews.com/story/news/politics/2020/04/23/democrats-plan-censure-lawmaker-whitsett-credited-trump-covid-19-recovery/3010947001/