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Interleukin 6 Inhibitors
PS…I don't trust any paper from the Lancet
Interleukin-6 inhibitor/ inhibitors
https://www.sciencedirect.com/science/article/abs/pii/S0163725813001939
Associate editor: B. Teicher
Targeting interleukin-6 in inflammatory autoimmune diseases and cancers
Author links open overlay panelXinYaoaJiaqiHuangaHaihongZhongaNanShencRaffaellaFaggionibMichaelFungaYihongYaoa
https://doi.org/10.1016/j.pharmthera.2013.09.004
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Abstract
Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal role in host defense against pathogens and acute stress. However, increased or deregulated expression of IL-6 significantly contributes to the pathogenesis of various human diseases. Numerous preclinical and clinical studies have revealed the pathological roles of the IL-6 pathway in inflammation, autoimmunity, and cancer. Based on the rich body of studies on biological activities of IL-6 and its pathological roles, therapeutic strategies targeting the IL-6 pathway are in development for cancers, inflammatory and autoimmune diseases. Several anti-IL-6/IL-6 receptor monoclonal antibodies developed for targeted therapy have demonstrated promising results in both preclinical studies and clinical trials. Tocilizumab, an anti-IL-6 receptor antibody, is effective in the treatment of various autoimmune and inflammatory conditions notably rheumatoid arthritis. It is the only IL-6 pathway targeting agent approved by the regulatory agencies for clinical use. Siltuximab, an anti-IL-6 antibody, has been shown to have potential benefits treating various human cancers either as a single agent or in combination with other chemotherapy drugs. Several other anti-IL-6-based therapies are also under clinical development for various diseases. IL-6 antagonism has been shown to be a potential therapy for these disorders refractory to conventional drugs. New strategies, such as combination of IL-6 blockade with inhibition of other signaling pathways, may further improve IL-6-targeted immunotherapy of human diseases.
Full Length article
Keywords
Interleukin-6
Autoimmune
Inflammation
Cancer
Targeted therapy
Monoclonal antibody
Abbreviations
AMLacute myeloid leukemia
COPDchronic obstructive pulmonary disease
CRCcolorectal cancer
CRPC-reactive protein
CSCcancer stem cells
DLTdose-limiting toxicity
EAEexperimental autoimmune encephalitis
EGFRepidermal growth factor receptor
IBDinflammatory bowel diseases
IFNinterferon
IL-6interleukin-6
IL-6RIL-6 receptor
mAbmonoclonal antibody
MMmultiple myeloma
MSmultiple sclerosis
MTXmethotrexate
NSCLCnon-small cell lung cancer
RArheumatoid arthritis
RCCrenal cell carcinoma
sgp130soluble gp130
sIL-6Rsoluble IL-6R
SJIAsystemic juvenile idiopathic arthritis
SLEsystemic lupus erythematosus
SOCSsuppressor of cytokine signaling
SScsystemic sclerosis
STATsignal transducers and activators of transcription
TAMtumor-associated macrophage
TLRToll-like receptor
TNFtumor necrosis factor
VEGFvascular endothelial growth factor
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Copyright © 2013 Elsevier Inc. All rights reserved.
Tocilizumab, an anti-IL-6 receptor antibody, is effective in the treatment of various autoimmune and inflammatory conditions notably rheumatoid arthritis. It is the only IL-6 pathway targeting agent approved by the regulatory agencies for clinical use. Siltuximab, an anti-IL-6 antibody, has been shown to have potential benefits treating various human cancers either as a single agent or in combination with other chemotherapy drugs. Several other anti-IL-6-based therapies are also under clinical development for various diseases. IL-6 antagonism has been shown to be a potential therapy for these disorders refractory to conventional drugs. New strategies, such as combination of IL-6 blockade with inhibition of other signaling pathways, may further improve IL-6-targeted immunotherapy of human diseases.
Possible cure all for a great deal of illnesses/cancer…If an inhibitor is found.
Interferon??? Is Interferon a More suitable choice???
I would never trust a Bill Gates or Fauci recommended drug like Trial bomber Remdesivir
Patent: Communist China and manufactured there. Gilead