Anonymous ID: 25ff72 May 1, 2020, 10:30 a.m. No.8989245   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun   >>9285

>>8989094 (lb)

Because the symptoms are caused by our immune response to the invader, not by the invader itself.

 

The treatment aids the immune response by killing destroying the invader, in situ, resulting in the immune system having nothing to attack.

 

SNIP

 

Chloroquine inhibits the action of heme polymerase in malarial trophozoites, preventing the conversion of heme to hemazoin.11,15,16 Plasmodium species continue to accumulate toxic heme, killing the parasite.11

 

Chloroquine passively diffuses through cell membranes and into endosomes, lysosomes, and Golgi vesicles; where it becomes protonated, trapping the chloroquine in the organelle and raising the surrounding pH.10,13 The raised pH in endosomes, prevent virus particles from utilizing their activity for fusion and entry into the cell.14

 

Chloroquine does not affect the level of ACE2 expression on cell surfaces, but inhibits terminal glycosylation of ACE2, the receptor that SARS-CoV and SARS-CoV-2 target for cell entry.13,14 ACE2 that is not in the glycosylated state may less efficiently interact with the SARS-CoV-2 spike protein, further inhibiting viral entry.14

 

https://www.drugbank.ca/drugs/DB00608

Anonymous ID: 25ff72 May 1, 2020, 10:37 a.m. No.8989395   ๐Ÿ—„๏ธ.is ๐Ÿ”—kun   >>9449

>>8989259

Only 2,600 Healthcare providers in the US actually input data into the Flu Surveillance system. Patients not seen by these providers are not usually tested nor are their numbers reported.

 

https://www.cdc.gov/flu/weekly/overview.htm

 

  1. Outpatient Illness Surveillance

 

Information on outpatient visits to health care providers for influenza-like illness is collected through the U.S. Outpatient Influenza-like Illness Surveillance Network (ILINet). ILINet consists of outpatient healthcare providers in all 50 states, Puerto Rico, the District of Columbia and the U.S. Virgin Islands reporting approximately 60 million patient visits during the 2018-19 season. Each week, approximately 2,600 outpatient healthcare providers around the country report data to CDC on the total number of patients seen for any reason and the number of those patients with influenza-like illness (ILI) by age group (0-4 years, 5-24 years, 25-49 years, 50-64 years, and โ‰ฅ65 years). For this system, ILI is defined as fever (temperature of 100ยฐF [37.8ยฐC] or greater) and a cough and/or a sore throat without a known cause other than influenza. Sites with electronic health records use an equivalent definition as determined by public health authorities.