Anonymous ID: 578aee May 3, 2020, 9:24 p.m. No.9021241   🗄️.is 🔗kun   >>1338

Folks, looks like we've got nothing to worry about: the virus only kills liberals.

 

Testosterone, a key hormone in the context of COVID-19 pandemic

>Pro-inflammatory cytokines have a central role in the progression of COVID-19 infection. Reduction of cytokine activity and/or their receptors (anti-cytokine therapy), can be useful for treatment. In this context testosterone may downregulate inflammation. As a matter of fact, several studies carried out both in animals and humans showed that hypogonadism is associated with increased pro-inflammatory cytokines and that testosterone treatment reduces IL-1β, IL-6, and TNF-α [16]. Furthermore, the association between an increase of pro-inflammatory state and decline in testosterone is often observed in aging men [17] and in men with stable coronary artery disease [18]. Based on the above considerations, the hypothesis arises that testosterone may have a role in the cascade of events leading to progression of COVID-19 infection due to the cytokine storm. Suppression of ACE2 expression by inflammatory cytokines accompanied by the decrease of androgens and estrogens of the elderly, may establish a negative correlation between ACE2 expression and COVID-19 mortality [19].

 

>Measuring testosterone levels may be recommended at the time of an identified COVID-19 positive patient. At present data on testosterone can be collected systematically at one or more institutions. If values are low, use of testosterone may be considered to reduce the associated pulmonary syndrome, thus preventing progression to severe COVID-19 disease where pro-inflammatory cytokines play a major role. In a further selection of patients for testosterone treatment, avoidance of enrolling patients in whom therapy with the hormone is contraindicated, should be taken into account. A proper randomized trial with testosterone should be then designed.

 

https://archive.is/k1gvg

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7185012/