N-Acetyl-Cysteine (NAC) is an inexpensive and easy to access over the counter supplement. It is the rate limiting chemical for the creation of our most powerful anti-oxidant glutathione (GSH). Think reduction in cytokine storm.

NAC by mouth or intravenously is used to reverse tylenol / paracetamol overdose. Think liver repair.

When nebulized, NAC is used to break up mucus in the lungs in cystic fibrosis. Think reduction in hypoxia and lung damage.

NAC also appears to have an anti-clotting effect. It appears that clotting is what causes death in those with COVID-19. Think prevention of multi-system organ failure.

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N-acetylcysteine: A rapid review of the evidence for effectiveness in treating COVID-19

https://www.cebm.net/covid-19/n-acetylcysteine-a-rapid-review-of-the-evidence-for-effectiveness-in-treating-covid-19/

N-acetylcysteine reduces the size and activity of von Willebrand factor in human plasma and mice

https://www.ncbi.nlm.nih.gov/pubmed/21266777

https://www.jci.org/articles/view/41062/figure/2

N-acetylcysteine inhibits thrombosis in a murine model of myeloproliferative neoplasm

https://ashpublications.org/bloodadvances/article/4/2/312/431284/N-acetylcysteine-inhibits-thrombosis-in-a-murine

Potent Thrombolytic Effect of N-Acetylcysteine on Arterial Thrombi

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.117.027290

NAC in COVID19 - Trial pending

https://clinicaltrials.gov/ct2/show/NCT04374461