Predictive Programming

First, here is the timeline of early Microsoft

Remember, Bill Gates was given the job and the money

By people working in the shadows.

He was part of a bigger plan than his software business

1980 August Product Microsoft signs a contract with IBM to develop an operating system for IBM's first personal computer. This, in turn, was the beginning for both the Bundling of Microsoft Windows, and Wintelism, as IBM personal computers and Intel were also bundled with each other.

1981 July 27 Product Microsoft buys the rights for QDOS from Seattle Computer Products (without telling SCP that it had a lucrative contract with IBM). This would later become MS-DOS.

1981 August 12 Company IBM announces the release of the IBM Personal Computer, which becomes the dominant personal computer. As DOS was the only operating system available on the PC when it was introduced in New York City, this paves way to the future domination by the MS-DOS operating system.

1982 April International Microsoft formally launches its International Division and sets up subsidiaries in Europe and elsewhere, finding local agents to handle its business interests

On March 8, 1982 this episode of Little House On the Prairie was released. Even though it was about events in the 1918-1920 timeframe, we should stick with the date 1982 as the date when this knowledge existed.

Quinoline is the core structure of many molecules including Quinine and Hydroxychloroquine. If you take the time to dig, you will find thousands of scientific papers discussing numerous drugs with quinoline components in their molecule, which are used to combat fevers and viral diseases. Many CONNECTIONS and the MAP TO DRAW is very large.

So lets Ask the Q. Why are there so few possible treatments for viral outbreaks? Why are we being steered to only one cure, namely vaccines?

ANTIMICROBIAL AND ANTIMALARIAL ACTIVITIES OF EXTRACTS ISOLATED FROM HERBAL PLANT POLYGONUM HYDROPIPER

NOTE: Polygonum hidropiper is also known as Persicaria hidropiper and is commonly referred to as Waterpepper in many languages

https://www.biotechlink.org/2-2018/article5

INTRODUCTION

Polygonum hydropiper (L.) belongs to the family of Polygonaceae. The species is commonly known as marsh-pepper smartweed, marsh-pepper knotweed, smartweed, or water pepper [1, 2]. The plant generally grows in wet areas at watersides and in marshes and is usually predominant in agricultural fields. It is also commonly distributed to highland sites with highly organic, moist, or silty areas [3].

P. hydropiper has a strong peppery taste and is commonly used as a hot-tasting spice, food flavor, and garnish for a variety of traditional dishes. The Japanese people use the young shoot as spice and garnish with raw fish such as “sashimi” for its pungent taste. In Southeast Asia, the Chinese and Malays use the leaves in traditional dishes [2]. P. hydropiper also has a wide range of traditional uses for medicinal purposes. P. hydropiper and other species of Polygonaceae are used to treat fever, chill, joint pain, oedema and infectious diseases for more than 300 years in Chinese folk medicine [4].

Domestically the plant is used as anti-inflammatory, carminative, astringent, diuretic, CNS stimulant, diaphoretic, stomachic, emmenagogue, anthelmintic, in bleeding disorders and in diarrhea [5]. Moreover it is also used to treat rheumatoid arthritis [6], Prostate gland inflammation, diarrhea [7], insomnia, kidney diseases, hemorrhoids [8], hypertension, angina and other cardiovascular diseases [9, 10].

Antibacterial and antifungal activities of individual compounds isolated from P. hydropiper are studied earlier. Confertifolin isolated from the leaf essential oil showes strong/good antibacterial activity against Enterococcus faecalis (MIC 31.25 𝜇g/mL) [11], Bacillus subtilis (minimum bactericidal concentration, MBC 100 𝜇g/mL), Staphylococcus aureus (MBC 100 𝜇g/mL), Escherichia coli (MBC 100 𝜇g/mL), and Salmonella choleraesuis (MBC 50 𝜇g/mL) [12]. Moreover, confertifolin is also found to have potent antifungal activity against Epidermophyton floccosum, Curvularia lunata, and Scopulariopsis sp. (MIC 7.81 𝜇g/mL) and moderate activity against Aspergillus niger, Botrytis cinerea, Magnaporthe grisea, Trichophyton mentagrophytes, Trichophyton rubrum (MTCC 296 and clinical isolate) and Trichophyton simii (MIC 16.62–125 𝜇g/mL) as compared to fluconazole (MIC < 12.5 – 100 𝜇g/mL) and ketoconazole (MIC < 12.5 𝜇g/mL) [11]. Polygodial is also reported to inhibit Candida albicans, C. utilis, C. krusei, Cryptococcus neoformans, Saccharomyces cerevisiae, Epidermophyton floccosum, Trichophyton mentagrophytes, T. rubrum, and Penicillium marneffei [13, 14]. It showes potent fungicidal activity against C. albicans [13]. In another studies, polygodial isolated from Warburgia species and P. hydropiper show fungicidal activity against S. cerevisiae [15, 16].

In the present article, we examine the antimicrobial, antimalarial and antifungal activities of some extracts of P. hydropiper.