Kawasaki disease and vaccinations
Kawasaki disease first appeared in the 1960s, and its frequency in developed nations marched upward right along with the expansion of the immunization schedule. It is a serious immune disorder that has been associated with several vaccines in clinical trials and case reports, including Hepatitis B, Rotavirus, Yellow fever, Pneumococcal conjugate, Influenza, and Group B meningococcal vaccines. Kawasaki disease is uncommon; it is severe; its cause is unknown; finally, it occurs predominantly in young children who are being intensively vaccinated. In spite of these distinctive features, vaccinations are almost never mentioned in general discussions of Kawasaki disease, and fewer than one in 100 cases are reported to VAERS, the adverse event reporting system managed in the US by the CDC and the FDA.
There are at least two other "mystery diseases" whose associations with vaccinations have never been resolved, one way or the other, by unbiased and properly controlled trials: SIDS and acute flaccid myelitis/AFM.
https://www.bmj.com/content/367/bmj.l6447/rr-3
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899743/
1 In contrast, various vaccines, including those against rotavirus, hepatitis B, and influenza, have been suggested to be triggers for KD occurrence
In conclusion, the present single case supports the suggestion that vaccination triggers KD. Information on cases of KD associated with vaccination should be accumulated to clarify the pathophysiology or etiology of KD.