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Anonymous ID: f30bbf May 24, 2020, 1:12 p.m. No.9300667   🗄️.is 🔗kun

Curtis Sliwa defies de Blasio no-swimming order in front of Parks cops

 

Curtis Sliwa hopped into the water off Coney Island on Sunday, defying Mayor Bill de Blasio’s no-swimming order — and mocking hapless city Parks Department cops who watched him from shore as a crowd cheered him on.

The mayor had warned last week, “Anyone tries to get in the water, they’ll be taken right out of the water,” while also threatening summonses for violators as the city battles to keep the coronavirus under control by banning swimming for now.

But Sliwa, dressed in a wet suit — and his trademark red Guardian Angels beret — strolled into the surf and swam around for about an hour without consequence, while a crowd of people on a pier near the old Parachute Jump cheered for him.

Seven or eight Parks officers tried ordering the Guardian Angels’ founder and mayoral candidate out of the drink at one point, but when he refused, they just stood and stared from the sand.

 

“I slowly walked into the water, and the Parkies are apoplectic, they don’t know what to do,” Sliwa recalled to The Post. “They start blowing their whistles as if they were lifeguards, screaming, ‘Come back! Come back!’ And I just keep going deeper and deeper and deeper.

“The whole concept is, this is our beach, not de Blasio’s. We pay for it. We’re taxpayers. Everybody else gets to swim in Long Island, Jersey Shore, Mediterranean. Not us? No, no, no.”

Before he took his first dip, Sliwa, who announced in March that he is running for mayor, buried an “effigy” of de Blasio in the sand. It consisted of a foot-high cardboard cut-out of the mayor’s head glued to a stick.

“I buried an effigy of de Blasio, right up to his head, so you could see his whole face. And I started kicking sand in his face, because of his edict that you could not swim in the water,” Sliwa said.

 

https://nypost.com/2020/05/24/curtis-sliwa-defies-de-blasio-swim-ban-in-front-of-parks-cops/

Anonymous ID: f30bbf May 24, 2020, 1:37 p.m. No.9300977   🗄️.is 🔗kun   >>1015

>>9300725

Moar:

Model based approach for estimating the dosage regimen of indomethacin a potential antiviral treatment of patients infected with SARS CoV-2

 

Abstract

To face SARS-CoV-2 pandemic various attempts are made to identify potential effective treatments by repurposing available drugs. Among them, indomethacin, an anti-inflammatory drug, was shown to have potent in-vitro antiviral properties on human SARS-CoV-1, canine CCoV, and more recently on human SARS-CoV-2 at low micromolar range. Our objective was to show that indomethacin could be considered as a promising candidate for the treatment of SARS-CoV-2 and to provide criteria for comparing benefits of alternative dosage regimens using a model-based approach. A multi-stage model-based approach was developed to characterize % of recovery and viral load in CCoV-infected dogs, to estimate the PK of indomethacin in dog and human using published data after administration of immediate (IR) and sustained-release (SR) formulations, and to estimate the expected antiviral activity as a function of different assumptions on the effective exposure in human. Different dosage regimens were evaluated for IR formulation (25 mg and 50 mg three-times-a-day, and 25 mg four-times-a-day), and SR formulation (75 mg once and twice-a-day). The best performing dosing regimens were: 50 mg three-times-a-day for the IR formulation, and 75 mg twice-a-day for the SR formulation. The treatment with the SR formulation at the dose of 75 mg twice-a-day is expected to achieve a complete response in three days for the treatment in patients infected by the SARS-CoV-2 coronavirus. These results suggest that indomethacin could be considered as a promising candidate for the treatment of SARS-CoV-2 whose potential therapeutic effect need to be further assessed in a prospective clinical trial.

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7237801/