Here are the main clinical trials of hydroxychloroquine for first responders

 

NOTE: The clinical term for these studies is PrEP, which stands for Pre-Exposure Prophylaxis. All of the following studies involve PrEP. The studies with the soonest expected date of completion are the Ford Health System (June 30, 2020) and Duke University (July 2020).

Duke University: HERO HCQ Study

 

Patient-Centered Outcomes Research Institute committing $50 million

 

double-blind, placebo-controlled, randomized trial with treatment course of 30 days.

 

15,000 patients at 17 locations in 12 states

 

Principal investigator: Adrian Hernandez, M.D., cardiologist and executive director of Duke Clinical Research Institute

 

Estimated primary completion date: July 2020

 

University of Minnesota with Rising Pharmaceuticals, Inc.

 

3,500 healthcare workers or household contacts exposed to Covid-19.

 

Randomized, controlled and quadruple blinded

 

Principal investigator: Radha Rajasingham, MD

 

Expected completion date: August 2020.

 

NYU Langone Health

 

350 participants, health care workers (HCWs) at high risk of occupational exposure to SARS-CoV-2

 

Controlled but non-randomized

 

Principal investigator: Howard Belmont

 

Expected date of completion: Aug. 1, 2020

 

Henry Ford Health System, Dearborn Michigan

 

3,000 participants: healthcare workers (HCW), Nursing Home Workers (NHW), first responders (FR), and Detroit Department of Transportation bus drivers (DDOT) in SE, Michigan

 

Randomized and triple blinded

 

Principal investigator: William W. O’Neill

 

Expected completion date: June 30, 2020.

 

Oxford University

 

Randomized, double-blinded, controlled study in healthcare workers throughout Asia, Africa and Europe

 

Workers in Europe and Africa will receive hydroxychloroquine

 

Workers in Asia will receive chloroquine

 

40,000 participants

 

Expected date of completion: April 2021

 

Principal contact: William Schilling, MD

 

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