Anonymous ID: 14c731 May 26, 2020, 1:19 p.m. No.9322570   🗄️.is 🔗kun   >>2960

>>9321996 pb

>Not sure baking soda would do it alone.

 

Yeah. It's probably overstated. But it does do what it does do. Slows growth, prevents spread.

 

Seems like you're good at curing cancer. It seems like one of the most difficult parts is getting the person to do the things you want them to do. Often, they say "well the doctor didn't say to do that, so, I'm not going to do that". And then they die. That was my experience.

Anonymous ID: 14c731 May 26, 2020, 1:25 p.m. No.9322618   🗄️.is 🔗kun   >>2925

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718030/

 

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

 

(This might be one of the reasons why (((they))) don't want people taking HCQ - they don't want people to accidentally cure cancer)

 

Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety of drugs, potentiating the therapeutic activity. Thus far, clinical results are mostly in favour of the repurposing of CQ. However, over 30 clinical studies are still evaluating the activity of both CQ and HCQ in different cancer types and in combination with various standard treatments. Interestingly, CQ and HCQ exert effects both on cancer cells and on the tumour microenvironment. In addition to inhibition of the autophagic flux, which is the most studied anti-cancer effect of CQ and HCQ, these drugs affect the Toll-like receptor 9, p53 and CXCR4-CXCL12 pathway in cancer cells. In the tumour stroma, CQ was shown to affect the tumour vasculature, cancer-associated fibroblasts and the immune system. The evidence reviewed in this paper indicates that both CQ and HCQ deserve further clinical investigations in several cancer types. Special attention about the drug (CQ versus HCQ), the dose and the schedule of administration should be taken in the design of new trials.

Anonymous ID: 14c731 May 26, 2020, 2:03 p.m. No.9322925   🗄️.is 🔗kun   >>2973

>>9322618

 

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3984580/

 

Acidic extracellular pH neutralizes the autophagy-inhibiting activity of chloroquine

 

(as I read that - chloroquine works better with baking soda, or other alkaline)

 

"The lack of CQ activity was likely dependent on a dramatically reduced cellular uptake at acidic pH. Using cell lines stably adapted to chronic acidosis we could confirm that CQ lack of activity was merely caused by acidic pH."(

 

(So, maybe Baking soda raises the pH, which allows the CQ into to the tumors?)

 

"suggesting that inhibition of autophagy and buffering of tumor pH may synergize in reducing tumor growth."

 

"Chloroquine and its derivative hydroxychloroquine (HCQ) are the only autophagy-inhibiting agents currently investigated in clinical trials in solid tumors."

Anonymous ID: 14c731 May 26, 2020, 2:10 p.m. No.9322973   🗄️.is 🔗kun

>>9322925

 

https://www.invivogen.com/chloroquine

 

Endosomal Acidification Inhibitor

 

Chloroquine is a lysosomotropic agent that prevents endosomal acidification [1]. It accumulates inside the acidic parts of the cell, including endosomes and lysosomes.

 

This accumulation leads to inhibition of lysosomal enzymes that require an acidic pH, and prevents fusion of endosomes and lysosomes.

 

Chloroquine is commonly used to study the role of endosomal acidification in cellular processes [2, 3], such as the signaling of intracellular TLRs.

 

Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation [4].