dChan
Anonymous ID: 7bd9d4 July 10, 2020, 5:41 p.m. No.9920546   🗄️.is 🔗kun   >>0579

>>9920249 lb

 

Quercetin is a zinc ionophore. Also EGCG (Epigallocatechin Gallate) found in strong Green Tea.

 

If you save it and only take it when you feel cold symptoms, that is best. Vitamin C and Zinc should be taken daily during the cold and flu season. Keep black elderberry on hand to take it when you feel a cold beginning.

 

Quinine is useless unless you get the bark and make up a tonic with the correct strength. ANd you need to beware of overdose with Quinine. The quinoline drugs that are effective are all prescription only for humans.

 

If you are hunting for videos to learn what to do, you may as well kill yourself now. This movement is not about replacing one set of gods with another. It is about waking up and freeing yourself.

 

Use Pubmed to find information

 

https://pubmed.ncbi.nlm.nih.gov/

 

And if you need to do background research to understand what they are talking about, then do it!!!

 

Want to learn more about an image? Then do an image search to find websites where it is used.

Anonymous ID: 7bd9d4 July 10, 2020, 5:43 p.m. No.9920579   🗄️.is 🔗kun   >>0599

>>9920546

Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model

 

https://pubs.acs.org/doi/pdf/10.1021/jf5014633

 

Abstract

Labile zinc, a tiny fraction of total intracellular zinc that is loosely bound to proteins and easily interchangeable, modulates the activity of numerous signaling and metabolic pathways. Dietary plant polyphenols such as the flavonoids quercetin (QCT) and epigallocatechin-gallate act as antioxidants and as signaling molecules. Remarkably, the activities of numerous enzymes that are targeted by polyphenols are dependent on zinc. We have previously shown that these polyphenols chelate zinc cations and hypothesized that these flavonoids might be also acting as zinc ionophores, transporting zinc cations through the plasma membrane. To prove this hypothesis, herein, we have demonstrated the capacity of QCT and epigallocatechin-gallate to rapidly increase labile zinc in mouse hepatocarcinoma Hepa 1-6 cells as well as, for the first time, in liposomes. In order to confirm that the polyphenols transport zinc cations across the plasma membrane independently of plasma membrane zinc transporters, QCT, epigallocatechin-gallate, or clioquinol (CQ), alone and combined with zinc, were added to unilamellar dipalmitoylphosphocholine/cholesterol liposomes loaded with membrane-impermeant FluoZin-3. Only the combinations of the chelators with zinc triggered a rapid increase of FluoZin-3 fluorescence within the liposomes, thus demonstrating the ionophore action of QCT, epigallocatechin-gallate, and CQ on lipid membrane systems. The ionophore activity of dietary polyphenols may underlay the raising of labile zinc levels triggered in cells by polyphenols and thus many of their biological actions.