HCQ inhibits HIV?

 

2003:

Effects of chloroquine on viral infections: an old drug against today’s diseases

Effects on HIV infection, Anti-HIV effects of chloroquine

"The anti-HIV activity of chloroquine has been shown not only in cell line models, but also in peripheral blood lymphocytes and monocytes —ie, cell culture models in which cellular uptake of chloroquine is closer to the conditions occurring in vivo. Under these conditions, it was possible to obtain levels of inhibition of viral replication above 90%."

DOI:https://doi.org/10.1016/S1473-3099(03)00806-5

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(03)00806-5/fulltext

https://archive.vn/cTZGM

 

''(I found a bunch of HCQ <HIV studies)''

1996:

Inhibition of HIV-1 replication by hydroxychloroquine: mechanism of action and comparison with zidovudine

"HCQ suppressed HIV-1 replication in a dose-dependent manner in both recently and chronically infected T-cell and monocytic cell lines."

https://www.clinicaltherapeutics.com/article/S0149-2918(96)80063-4/fulltext

https://archive.vn/LK3QV

 

1993:

Inhibition of Human Immunodeficiency Virus Type 1 Replication by Hydroxychloroquine in T Cells and Monocytes

"These data suggest that HCQ may be useful adjunctive therapy in the treatment of HIV-1 infection."

https://pubmed.ncbi.nlm.nih.gov/8427717/?dopt=Abstract

https://archive.vn/06fWY

 

1995:

Hydroxychloroquine Treatment of Patients With Human Immunodeficiency Virus Type 1

"The amount of recoverable HIV-1 RNA in plasma declined significantly in the HCQ group over the 8-week period (P = 0.022), while it increased in the placebo group."

https://pubmed.ncbi.nlm.nih.gov/8565026/?dopt=Abstract

https://archive.vn/18UXF

https://archive.vn/M8iZr

 

1996:

The Antiinflammatory and Antiviral Effects of Hydroxychloroquine in Two Patients With Acquired Immunodeficiency Syndrome and Active Inflammatory Arthritis

"HCQ may exert simultaneous anti-inflammatory and antiviral effects in patients with HIV infection and inflammatory arthritis. If larger studies confirm this observation, it may be the drug of choice in this population of patients."

https://pubmed.ncbi.nlm.nih.gov/8546725/?dopt=Abstract

https://archive.vn/Dyfy0

 

2004:

Chloroquine and Hydroxychloroquine as Inhibitors of Human Immunodeficiency Virus (HIV-1) Activity

"Chloroquine and its analog hydroxychloroquine are two inexpensive agents that are widely used for the treatment of malaria and have been shown to achieve some level of anti-HIV activity."

https://pubmed.ncbi.nlm.nih.gov/15320751/

https://archive.vn/AskWC

 

2001:

The anti-HIV-1 activity of chloroquine.

"Interestingly, CQ is capable of inhibiting HIV-1 replication at concentrations within the range reported in plasma of individuals chronically treated with doses of the drug which have well-known and limited toxicity."

https://pubmed.ncbi.nlm.nih.gov/11166661/

https://archive.vn/aXgYF

 

2002:

Hydroxychloroquine, hydroxycarbamide, and didanosine as economic treatment for HIV-1

"This new combination of drugs could be suitable for countries that have restricted resources"

https://pubmed.ncbi.nlm.nih.gov/12020529/

https://archive.vn/Ne1jY

 

2005:

Hydroxychloroquine, hydroxyurea and didanosine as initial therapy for HIV-infected patients with low viral load: safety, efficacy and resistance profile after 144 weeks

"This novel and well-tolerated combination controls viral replication during long-term follow up, with development of few resistance mutations. With careful monitoring it may be a useful strategy for delaying highly active antiretroviral therapy (HAART) and associated toxicity in selected patients with low initial viral loads."

https://pubmed.ncbi.nlm.nih.gov/15670247/

https://archive.vn/76fxQ

 

Small sampling of studies

Imagine if HCQ was widely prescribed and suddenly HIV positive people began testing HIV negative.