Yes.
The US economy is undergoing a great transition due to the lockdown and resurgence. Many will have opportunities to do something new and different. America is also bringing back supply chains from overseas and undoing the horrible "off-shoring" trend that took off during the mid-1990s.
These are some of the foreseeable changes.
I believe there are also a lot of unforeseeable changes in the works, which will also create tremendous opportunities, for those who are nimble and resourceful.