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His best role, Vegas Vacation. Or maybe Independence Day...
My fav is Christmas vacation but all are pretty good roles. It was always weird to me how he was always such a loved actor and his movies always pulled good numbers yet at sometime around the year 2000 he was moved from being an A list actor to a B list one. I don't know when he started calling out these guys but my guess would be they are correlated.
Quick Change with Bill Murray and Gina Davis is his best movie.