>>74008

'''the mission never sleeps'''

1 of 2

NSA headquarters at night, official NSA-supplied photo originally titled "The Mission Never Sleeps"

https://en.wikipedia.org/wiki/Wikipedia:Surveillance_awareness_day/Brainstorming_phase

{ https://archive.ph/57BYB / https://archive.ph/YitCt rev.HIST }

{ caveat }:

This page is currently inactive and is retained for historical reference.

Either the page is no longer relevant or consensus on its purpose has become unclear.

To revive discussion, seek broader input via a forum such as the village pump.

NOTICED THIS { picrel }:

The Information Awareness Office was established by the Defense Advanced Research Projects Agency (DARPA) in January 2002

to bring together several DARPA projects focused on applying surveillance and information technology to achieve

"Total Information Awareness".

The office's logo featured an all-seeing eye atop a pyramid using a golden light to scan the planet Earth. {LIFELOG}

The logo included the motto scientia est potentia – knowledge is power.

https://en.wikipedia.org/wiki/Information_Awareness_Office { https://archive.ph/bpRTv / https://archive.ph/3OvKi rev.HIST }

https://qagg.news/?wordsearch=on&q=knowledge+is+power (18) QPosts - screenCAP

last img, work in progress

>>74032

> the mission never sleeps

2 of 2

I.A.O.{ wizeOwlz }

>bring together several DARPA projects focused on applying surveillance and information technology to achieve

>"Total Information Awareness".

>>74032

> { caveat }:

CAP

ongoing qresearch: Graphene + Nanotech + Medicine

"KNOWINGLY" { Published online 11 December 2015, yet how much was known before this !?! }

NanomedicineVol. 11, No. 1 Review

The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery

Claudia Corbo, Roberto Molinaro, Alessandro Parodi, Naama E Toledano Furman, Francesco Salvatore & Ennio Tasciotti

Published Online:11 Dec 2015 https://doi.org/10.2217/nnm.15.188

In a perfect sequence of events, nanoparticles (NPs) are injected into the bloodstream where they circulate until they reach the target tissue.

The ligand on the NP surface recognizes its specific receptor expressed on the target tissue and the drug is released in a controlled manner.

However, once injected in a physiological environment, NPs interact with biological components and are surrounded by a protein corona (PC).

This can trigger an immune response and affect NP toxicity and targeting capabilities.

In this review, we provide a survey of recent findings on the NP–PC interactions and discuss how the PC can be used to modulate

both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers.

History

Published online 11 December 2015

Published in print January 2016

© Future Medicine Ltd { London, UK }

https://www.futuremedicine.com/doi/10.2217/nnm.15.188 { https://archive.ph/ymLGC }

moar NIH CONNECTIONS:

https://commonfund.nih.gov/nanomedicine/overview

Background

Nanomedicine, an offshoot of nanotechnology, refers to highly specific medical intervention at the molecular scale

for curing disease or repairing damaged tissues, such as bone, muscle, or nerve.

A nanometer is one-billionth of a meter, too small to be seen with a conventional lab microscope.

It is at this size scale – about 100 nanometers or less – that biological molecules and structures operate in living cells.

The NIH vision for Nanomedicine is built upon the strengths of NIH funded researchers in probing and understanding the biological,

biochemical and biophysical mechanisms of living tissues. Since the cellular machinery operates at the nanoscale,

the primary goal of the program - characterizing the molecular components inside cells at a level of precision that leads

to re-engineering intracellular complexes - is a monumental challenge.

>>74080

>Nanomedicine

Nanomedicine, Vol. 14, No. 7 | Review

Delivering DNA origami to cells

Dhanasekaran Balakrishnan, Gerrit D Wilkens & Jonathan G Heddle

Published Online:22 Mar 2019 https://doi.org/10.2217/nnm-2018-0440

Abstract

DNA nanotechnology research has long-held promise as a means of developing functional molecules capable of delivery to cells. Recent advances in DNA origami have begun to realize this potential but is still at the earliest stage and a number of hurdles remain. This review focuses on progress in addressing these hurdles and considers some of the challenges still outstanding. These include stability of such structures necessary to reach target cells after administration; methods of cell targeting and uptake; strategies to avoid or escape endosomes and techniques for achieving specific subcellular localization. Finally, the functionality that can be expected once DNA origami structures reach their final intracellular targets will be considered.

Lay abstract

The DNA origami technique allows ‘nanorobots’ to be made from DNA. These have the potential to work as ‘smart’ drugs but only if they can be successfully delivered to cells. Here, we review progress in achieving this goal.

https://www.futuremedicine.com/doi/10.2217/nnm-2018-0440 { https://archive.ph/v0t3Y }

Kirigami / origami nanoGRAPHENE >>69697, >>69827 /pB

>>74090

>DNA origami

does that compare to the White Rabbit

Molecular Structure of ...