>https://pubmed.ncbi.nlm.nih.gov/29737455/

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review

Domenico Plantone 1, Tatiana Koudriavtseva 2

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PMID: 29737455 DOI: 10.1007/s40261-018-0656-y

Abstract

The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects. Among the biological effects of chloroquine and hydroxychloroquine, it is important to highlight their antitumoral properties, likely due to their strong antiproliferative, antimutagenic, and inhibiting autophagy capacities. These effects make these drugs a possible option in the treatment of several tumors in association with radiotherapy and chemotherapy. Finally, the repurposing of chloroquine and hydroxychloroquine is currently being examined for neurological diseases such as neurosarcoidosis, chronic lymphocytic inflammation with pontine perivascular enhancement responsive to corticosteroids, and primary progressive multiple sclerosis. Several ongoing clinical trials have been testing these drugs in non-neoplastic and neoplastic diseases. Moreover, the well-demonstrated good tolerability of chloroquine and hydroxychloroquine make them safe even during pregnancy. Gastrointestinal and cutaneous manifestations are considered not to be serious, while retinal, neuromuscular, and cardiac toxicities are classified as serious adverse events.

wtf is q fever

More Evidence Emerges Showing Hydroxycholoquine is Effective Against Coronavirus

The controversial therapeutic drug Hydroxycholorquine (HCQ) is becoming the focal point once again. Vaccine efforts are still underway but more and more attention is being places on the anti-viral therapeutic. The President of Brazil, Jair Bolsonaro, tested positive for coronavirus and recovered quickly while taking the drug. He enthusiastically posted video of himself taking his dosage and later another video holding a packet overhead for a large cheering crowd.

Studies on the drugs effectiveness go back more than 50 years after the FDA first approved it in 1955. It’s derivative of chemicals discovered by Hans Andersag while he worked for Bayer in Germany. The family of drugs is effective against lupus, tumors, and various kinds of viral infections. The exact mechanism of the drug is not completely understood, but it’s presumed to somehow protect DNA by bonding with it.

After months of bashing hydroxychloroquine as untested, dangerous, and criticizing the President for taking it, much of the mainstream media has avoided talking about the drug lately. A new study released by the Henry Ford Foundation in Michigan shows the anti-viral drug can be quite helpful if taken during the early stages of a viral infection.

>https://repub.li/henry-ford-health-study-hcq-took-mortality-from-26-4-to-13-5/

Study Details:

2,541 Patients Participated in the Study with an average hospital stay of 6 days.

26.4% crude mortality rate for those getting neither drug

22.4% crude mortality rate for those getting azithromycin alone

20.1% crude mortality rate for those getting hydroxychloroquine + azithromycin

18.1% crude mortality rate for the entire group

13.5% crude mortality rate for those getting hydroxychloroquine alone

The full study was published in the International Journal of Infections Diseases.

As the debate about returning the school turns into a full on fight, questions about what’s really going on with the virus numbers are beginning to get more serious. The public gave great leeway to experts’ warnings, accepting lockdown and mask precautions. Weeks turned into months and despite great effort, the experts kept pressing for more closures.

Various anecdotal reports of questionable reporting practices and genuine failures paint a broader picture of intentional inflation. Dozens of reports from Florida have come in as 100% positive. Colorado has revised numbers down, sometimes as much as 25% at a time. Other states have been caught reporting the same case multiple times.

Various Governors have also been called out on policies that placed positive cases into nursing homes. Mixing a dangerous viral disease with then country’s most sensitive population is insanity. Temporary hospitals sat empty while the policy exposed many elderly and caused thousands of unnecessary deaths.

>https://pubmed.ncbi.nlm.nih.gov/29737455/

source article

>https://repub.li/more-evidence-showing-hydroxycholoquine-is-effective-against-coronavirus/