Dr. Anthony Fauci: ‘Of Course’ I Would Prescribe Chloroquine to Coronavirus Patients
March 25, 2020
https://www.breitbart.com/politics/2020/03/25/dr-anthony-fauci-of-course-i-would-prescribe-chloroquine-to-coronavirus-patients/
Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republic of China for treatment of COVID-19 infection in larger populations in the future
Chloroquine is a cheap and safe drug that has been used for more than 70 years. In light of the urgent clinical demand, chloroquine phosphate is recommended to treat COVID-19 associated pneumonia in larger populations in the future
*Address correspondence to: Jianjun Gao, Department of Pharmacology, School of Pharmacy, Qingdao University, Qingdao, Shandong, China
https://www.jstage.jst.go.jp/article/bst/advpub/0/advpub_2020.01047/_pdf
Chloroquine: “Its antiviral activities against the human immunodeficiency virus (HIV) [6] and the SARS coronavirus have been demonstrated”
“The potential of chloruine to be added to the limited range of anti-influenza drugs should be explored further, particularly since antiviral drugs play a vital role in influenza pandemic preparedness.”
“An alternative to this mode of drug discovery may be to find new uses for old drugs, where the availability of extensive experience with their clinical use may shorten the duration needed for the various phases of clinical trials. Chloroquine serves as such an example. Our results suggest that chloroquine has a clinically useful inhibitory activity against influenza A virus replication.”
“In conclusion, chloroquine demonstrates an inhibitory effect against the replication of human influenza A virus H1N1 and H3N2, in vitro and further studies to explore its therapeutic and prophylactic potential against influenza epidemics and pandemics should be encouraged.”
Published online 2006 May 29
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1481635/