dChan
Anonymous ID: 61b551 Aug. 18, 2020, 5:03 p.m. No.10335033   🗄️.is 🔗kun   >>5262 >>5343 >>5406 >>5460 >>5462 >>5641 >>5651

Anons

What do we know aboutOleandrin?

Raging Homo Anderson "Mommy killed my brother" Cooper is seriously kvetching during this interview with Mike Lindell.

Interview is just like how these fags reacted to HCQ treating Covid.

Idiot Cooper rags on Lindell for not being a "medical professional" and having an opinion about some drugs while Cooper is also NOT a medical professional who has an opinion about drugs. Not sure why that fag thinks his non medical opinion is any moar important than someone else's.

 

and what's with the purple CNN background?

 

also fake news all over the Olenadrin just like HCQ. Twatter had is splashed as top news complete with debunks and experts saying batshit crazy

 

https://twitter.com/girlsreallyrule/status/1295786193259552772

Anonymous ID: 61b551 Aug. 18, 2020, 5:30 p.m. No.10335262   🗄️.is 🔗kun   >>5343 >>5460 >>5583 >>5641

>>10335033

>Olenandrin

 

When administered both before and after virus infection, nanogram doses of oleandrin significantly inhibited replication by up to 3,000-fold, indicating the potential to prevent disease and virus spread in persons recently exposed 45to SARS-CoV-2, as well as to prevent severe disease in persons at high risk. These results indicate that oleandrin should be tested in animal models and in humans exposed to infection to determine its medical usefulness in controlling the pandemic.

 

linked off of the marketwatch article

Anonymous ID: 61b551 Aug. 18, 2020, 5:37 p.m. No.10335343   🗄️.is 🔗kun   >>5460 >>5641

>>10335033

>>10335262

 

The GlycosideOleandrin Reduces Glioma Growth with Direct and Indirect Effects on Tumor Cells

 

Abstract

 

Oleandrin is a glycoside that inhibits the ubiquitous enzyme Na+/K+-ATPase. In addition to its known effects on cardiac muscle, recent in vitro and in vivo evidence highlighted its potential for anticancer properties. Here, we evaluated for the first time the effect of oleandrin on brain tumors. To this aim, mice were transplanted with human or murine glioma and analyzed for tumor progression upon oleandrin treatment. In both systems, oleandrin impaired glioma development, reduced tumor size, and inhibited cell proliferation. We demonstrated that oleandrin does the following: (1) enhances the brain-derived neurotrophic factor (BDNF) level in the brain; (2) reduces both microglia/macrophage infiltration and CD68 immunoreactivity in the tumor mass; (3) decreases astrogliosis in peritumoral area; and (4) reduces glioma cell infiltration in healthy parenchyma. In BDNF-deficient mice (bdnftm1Jae/J) and in glioma cells silenced for TrkB receptor expression, oleandrin was not effective, indicating a crucial role for BDNF in oleandrin's protective and antitumor functions. In addition, we found that oleandrin increases survival of temozolomide-treated mice. These results encourage the development of oleandrin as possible coadjuvant agent in clinical trials of glioma treatment.

 

SIGNIFICANCE STATEMENT In this work, we paved the road for a new therapeutic approach for the treatment of brain tumors, demonstrating the potential of using the cardioactive glycoside oleandrin as a coadjuvant drug to standard chemotherapeutics such as temozolomide. In murine models of glioma, we demonstrated that oleandrin significantly increased mouse survival and reduced tumor growth both directly on tumor cells and indirectly by promoting an antitumor brain microenvironment with a key protective role played by the neurotrophin brain-derived neurotrophic factor

 

https://www.jneurosci.org/content/37/14/3926.abstract