Anonymous ID: 86b682 Oct. 16, 2020, 11:23 a.m. No.11105449   🗄️.is 🔗kun   >>5543 >>5667 >>5914 >>5966 >>6002

WHO back again with results from "study" claiming no medication works against COVID 1/2

 

link to pre-print of study:

https://www.medrxiv.org/content/10.1101/2020.10.15.20209817v1.full.pdf

 

NOTE: the study has not been peer-reviewed yet

 

Study:

 

Repurposed antiviral drugs for COVID-19 – interim WHO SOLIDARITY trial results

 

ABSTRACT

 

BACKGROUND

WHO expert groups recommended mortality trials in hospitalized COVID-19 of four re-purposed antiviral drugs.

 

METHODS

Study drugs were Remdesivir, Hydroxychloroquine, Lopinavir (fixed-dose combination with Ritonavir) and Interferon-β1a (mainly subcutaneous; initially with Lopinavir, later not). COVID-19 inpatients were randomized equally between whichever study drugs were locally available and open control (up to 5 options: 4 active and local standard-of-care). The intent-to-treat primary analyses are of in-hospital mortality in the 4 pairwise comparisons of each study drug vs its controls (concurrently allocated the same management without that drug, despite availability). Kaplan-Meier 28-day risks are unstratified; log-rank death rate ratios (RRs) are stratified for age and ventilation at entry.

 

RESULTS

In 405 hospitals in 30 countries 11,266 adults were randomized, with 2750 allocated Remdesivir, 954 Hydroxychloroquine, 1411 Lopinavir, 651 Interferon plus Lopinavir, 1412 only Interferon, and 4088 no study drug. Compliance was 94-96% midway through treatment, with 2-6% crossover. 1253 deaths were reported (at median day 8, IQR 4-14). Kaplan-Meier 28-day mortality was 12% (39% if already ventilated at randomization, 10% otherwise). Death rate ratios (with 95% CIs and numbers dead/randomized, each drug vs its control) were: Remdesivir RR=0.95 (0.81-1.11, p=0.50; 301/2743 active vs 303/2708 control), Hydroxychloroquine RR=1.19 (0.89-1.59, p=0.23; 104/947 vs 84/906), Lopinavir RR=1.00 (0.79-1.25, p=0.97; 148/1399 vs 146/1372) and Interferon RR=1.16 (0.96-1.39, p=0.11; 243/2050 vs 216/2050). No study drug definitely reduced mortality (in unventilated patients or any other subgroup of entry characteristics), initiation of ventilation or hospitalisation duration.

 

CONCLUSIONS

These Remdesivir, Hydroxychloroquine, Lopinavir and Interferon regimens appeared to have little or no effect on hospitalized COVID-19, as indicated by overall mortality, initiation of ventilation and duration of hospital stay. The mortality findings contain most of the randomized evidence on Remdesivir and Interferon, and are consistent with meta-analyses of mortality in all major trials. (Funding: WHO. Registration: ISRCTN83971151, NCT04315948)

 

Anon theory:

 

Did POTUS' admin know in advance they were going to time the release of a non peer-reviewed version of this "study" around the schedule of the US presidential election, and to counter the "neither HCQ nor Remdesivir nor Interferon nor Lopinavir/Ritonavir works" narrative (AKA the "COVID=DEATH SENTENCE" narrative), POTUS took BOTH Regeneron AND Remdesivir:

 

  1. Remdesivir to sidetrack the cabal -"muah ah ah, that fool doesn't know we're going to tank that crap med soon, we'll play along for now. But next, we'll tell everyone he was never sick in the first place"

 

  1. The WH was vague about the use of Regeneron, let it sound like Remdesivir was the main medication. The cabal smelt a rat though, and tried to attack the monoclonal antibody therapy

 

  1. POTUS comes back, only names Regeneron in his comeback video, and says he took other things, but he felt it was the Regeneron that did it

 

  1. MSM tried to downplay Regeneron, drawing attention to the fact he also took Remdesivir

 

  1. But now, thanks to that WHO "study", the public knows there is a medication that works, and that it cannot be Remdesivir, since the WHO just tanked it

 

  1. "POTUS was not sick" controversy avoided

"There is no cure/COVID=DOOM" controversy avoided

HCQ controversy [anons and awaken citizens still know it works]

 

If theory correct -nicely played 4D-game theory ladies and good sirs at the WH!

Anonymous ID: 86b682 Oct. 16, 2020, 11:28 a.m. No.11105498   🗄️.is 🔗kun   >>5543 >>5667 >>5914 >>5966

WHO back again with results from "study" claiming no medication works against COVID 2/2

 

Fox News article:

 

https://www.foxnews.com/health/four-coronavirus-treatments-remdesivir-hydroxychloroquine-flop-who-study

 

4 coronavirus treatments, including remdesivir, hydroxychloroquine, flop in large WHO study

Gilead Sciences, drug manufacturer of remdesivir, raised concerns over the data because it has yet to undergo 'rigorous review'

 

Four coronavirus drugs were found to have "little or no effect" on hospitalized patients, according to preliminary results from a World Health Organization study.

 

Anticipated findings from the WHO’s multi-country Solidarity trial were posted ahead of peer review in medRxiv on Thursday, which assessed remdesivir, hydroxychloroquine, interferon and an HIV-drug combo lopinavir-ritonavir.

 

“The main outcomes of mortality, initiation of ventilation and hospitalization duration were not clearly reduced by any study drug,” according to the study.

 

While hydroxychloroquine and lopinavir were dropped from the WHO trial over the summer over futility, the remdesivir findings directly contrast with results from a U.S. NIH-led study, which showed to shorten patients' path to recovery by about four to five days. Those results were recently upheld by a final report, of which John Beigel, associate director of clinical research in the division of microbiology and infectious disease at NIAID, told TIME that “these data reinforce the value of Remdesivir in hospitalized patients.”

 

The drug manufacturer of remdesivir, Gilead Sciences, released a statement voicing concerns over the WHO trial.

 

"The emerging data appear inconsistent with more robust evidence from multiple randomized, controlled studies published in peer-reviewed journals validating the clinical benefit of Veklury® (remdesivir)," company officials wrote. "We are concerned that the data from this openlabel global trial have not undergone the rigorous review required to allow for constructive scientific discussion, particularly given the limitations of the trial design."

 

Gilead previously ran its own clinical trials on the drug, and found that 65% of moderately ill patients had improvement after 11 days.

 

The WHO study involved over 11,000 adults across 405 hospitals in 30 countries on multiple treatments tested against a control arm; 2,750 patients were allocated remdesivir. (The NIH study involved 1,062 patients who were randomly assigned remdesivir or a placebo for 10 days.)

 

In the company statement sent to Fox News, Gilead pointed to the WHO trial's "significant heterogeneity in trial adoption, implementation, controls and patient populations" because the trial design prioritized broad access.

 

Dr. Soumya Swaminathan, WHO chief scientist, touted the Solidarity trial on Wednesday, calling it a "wonderful global collaboration" that benefited from preparations and investments made over the last few years, having learned from Ebola and other outbreaks. She said, in approaching the trials for COVID-19, investigators knew how to write protocols quickly, ideas were shared around the clock and drug manufacturers came forward to donate drugs.

 

She called it a "good experience" all-in-all, and on Wednesday before the data was released, she said next plans will involve monoclonal antibodies, immunomodulators and new antiviral drugs developed within the last few months.