Thespike proteinactivates intracellular signaling WITHOUT other components of the virus being present.
All sources of spike protein are fair game.
ALC-0159is one of the components of the BNT162b2 vaccine, against SC2, as well as ALC-0315, DSPC, and cholesterol.
his product is intended for research use ONLY and NOT for human use.
On the other hand, it is very confusing to read in the instruction sheet produced by the laboratory that produces it that
https://www.echelon-inc.com/product/alc-0159/
https://twitter.com/BidoliNicola/status/1435808251619291140
…it can damage by disrupting signals as well…
In the new study, the researchers created a “pseudovirus” that was surrounded by SARS-CoV-2 classic crown of spike proteins, but did not contain any actual virus. Exposure to this pseudovirus resulted in damage to the lungs and arteries of an animal model—proving that the spike protein alone was enough to cause disease. Tissue samples showed inflammation in endothelial cells lining the pulmonary artery walls.
The team then replicated this process in the lab, exposing healthy endothelial cells (which line arteries) to the spike protein. They showed that the spike protein damaged the cells by binding ACE2. This binding disrupted ACE2’s molecular signaling to mitochondria (organelles that generate energy for cells), causing the mitochondria to become damaged and fragmented.
https://www.salk.edu/news-release/the-novel-coronavirus-spike-protein-plays-additional-key-role-in-illness/
Abstract
The novel SARS-coronavirus 2 (SARS-CoV-2) poses a global challenge on healthcare and society. For understanding the susceptibility for SARS-CoV-2 infection, the cell type-specific expression of the host cell surface receptor is necessary. The key protein suggested to be involved in host cell entry is angiotensin I converting enzyme 2 (ACE2). Here, we report the expression pattern of ACE2 across 150 different cell types corresponding to all major human tissues and organs based on stringent immunohistochemical analysis. The results were compared with several datasets both on the mRNA and protein level. ACE2 expression was mainly observed in enterocytes, renal tubules, gallbladder, cardiomyocytes, male reproductive cells, placental trophoblasts, ductal cells, eye, and vasculature. In the respiratory system, the expression was limited, with no or only low expression in a subset of cells in a few individuals, observed by one antibody only. Our data constitute an important resource for further studies on SARS-CoV-2 host cell entry, in order to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7383091/
mAB cocktail, PEP in 'proper' high risk is likely advantageous… wreckless administration is not the way… also disadvantage is it will hinder your ability to produce natural immunity to the virus
It needs to be properly studied in pregnancy. As long as there are no detrimental effects we can assume it provides protection to the fetus and depending on if it gets into breast milk >protection for neonate… variables >> half-life, placental barrier crossing, presence is breast milk
>14596609
protects mother as well, neutralization
could be a good option in pregnancy
currently not enough research done
careful selection of non-overlapping antibodies makes it difficult for escape