do you mean "in vivo" anon? The following article lists in vivo dosages in Table 4:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
do you mean "in vivo" anon? The following article lists in vivo dosages in Table 4:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
There are several toxicological reports of ivermectin in different species. The lethal dose 50 (LD50) reported in mice [19] is 25 mg/kg administered orally, whose human equivalent dose (HED) is 2.02 mg/kg. The LD50 increases up to 30 mg/kg when this compound is administered intraperitoneally in mice (HED 2.43 mg/kg). For rats the average lethal dose is 50 mg/kg orally (HED 8.01 mg/kg) and 55 mg/kg intraperitoneally (HED 8.91 mg/kg). In rabbits it is 406 mg/kg in topical application, while in dogs it is 80 mg/kg administered orally (HED 43.24 mg/kg) [20]. Clearly, it seems that the higher the phylogenetic scale the lower toxicity by ivermectin. These data are in accord with the findings in a review paper on avermectins poisoning (14 on suicidal attempt). In this retrospective review, among 18 patients exposed to abamectin and one to ivermectin, 15 were poisoned by oral ingestion. Four were asymptomatic and 8 had minor symptoms with a mean ingestion of 23 mg/kg (range in 4.2-67 mg/kg). Seven patients manifested severe symptoms, such as coma (seven), aspiration with respiratory failure (four), and hypotension (three), after a mean ingestion of 100.7 mg/kg avermectin (15.4 mg/kg for ivermectin and 114.9 mg/kg for abamectin). All 7 seven patients received intensive supportive care; 1 patient died 18 days later as a result of multiple organ failure [21].
In humans it is considered that ivermectin generates low levels of toxicity because its targets are confined within the CNS. Indeed, most patients treated with ivermectin have no side-effects other than those caused by the immune and inflammatory responses against the parasite, such as fever, pruritus, skin rashes and malaise [7,22], and when present, they appear within 24-48 h after treatment [23]. Certainly, moderate symptoms such as arthralgia, dizziness, fever, skin edema, dyspnea and hypotension may be more related with the microfilarial load in the patient rather than with the intrinsic toxicity of ivermectin [24]. Reports on cases of encephalopathy in patients co-infected with onchocerciasis and lymphatic filariasis after 48 h of treatment with ivermectin can be found in the literature [25], but it is believed that this adverse reaction is due to the obstruction of the microcirculation of the brain by the accumulation of dead or paralyzed parasites, which leads to brain embolism [26].
In conclusion, the immense number of patients who have been treated with ivermectin shows that it is a safe and a well-tolerated drug. Beyond the side effects attributable to the immunological and inflammatory reaction elicited by dying or death parasites, there are sympathetic signs related to ivermectin intoxication, including tremors, mydriasis, sialorrhea, motor incoordination and coma [27].
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5835698/
np anon. best to find an IRL expert to confirm this with. those doses and durations are for mice and would need to be converted to their human equivalent dosages. you would also want to be professionally screened beforehand and monitored during treatment, etc. but certainly looks promising.