>>15821025(lb)
>the ACE-2 receptor able to send ANY intracellular signal when transitioned to ligand-bound state?
No, only correct "ligands". Covid hijacks the ACE2 receptor in order to enter the cell, while angiotensim converting enzyme, the native ligand, activates the RAS system mostly to control blood pressure. When the downstream system isn't activated, as expected, the body increases the number of ACE2 receptors, leaving the person more susceptible to infection.
That was the initial approach that they considered. Hypothetically it should have worked but they abandoned the idea.
Let me look it up a bit and see why. Could be receptor affinity where the Virus was able to displace the antagonist.
Kind of what I suspected. ACE2 inhibitors/blockers , like Covid, would send the equivalent of a null signal, resulting in increased expression. Sort of a standoff/draw.
https://advances.massgeneral.org/research-and-innovation/journal.aspx?id=1991
Since Covid increases ACE2 expression, if I was an evil biowarfare fuck then I would prime the population with covid, reverse transcriptase the spike instructions into DNA, then when the real weapon is ready, using the same entry receptor, send the spike protein manufacture signal to flood the body with billions of spike proteins, then release the real deadly weapon.
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That's what I based the meme off of.
And, to afford living in the suburbs away from the shithole, both parents had to go to work and surrender their chiLoren to public schooling.
Lindell>wrestling>MyPillow>sleeper hold
Wolverines!