Aphasia linked to PRION (CJD)?
(been reading about PRION and Aphesia)
January 17, 2006
PRIMARY PROGRESSIVE APHASIA AND PRION GENOTYPE, IS THERE A CONNECTION?
"A new study links primary progressive aphasia (PPA) with a common genotype of the prion protein (Ann Neurology 2005:58(6):858-864). The finding, termed “unusual” by its lead author, showed that a large fraction of the 39 PPA patients studied are heterozygous for a well-known polymorphism of the prion protein gene."
https://journals.lww.com/neurotodayonline/fulltext/2006/01170/primary_progressive_aphasia_and_prion_genotype__is.5.aspx
https://archive.ph/Nvae9
OCTOBER 01, 2010
Conduction aphasia as an initial symptom in a patient with Creutzfeldt–Jakob disease
"We report a 59-year-old woman who presented to our facility with conduction aphasia as an initial symptom which, within 3 months, was followed by generalized myoclonus and global aphasia… After a positive finding of the 14-3-3 protein in her cerebrospinal fluid, she was diagnosed as having probable sporadic Creutzfeldt–Jakob disease."
https://www.jocn-journal.com/article/S0967-5868(10)00251-1/fulltext
https://archive.ph/tNjmv
1985 Aug
Creutzfeldt-Jakob Disease Presenting as Progressive Aphasia
"This report is of a patient with progressive aphasia due to Creutzfeldt-Jakob disease."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2571142/
https://archive.ph/GBYzb
12 April 2016
Isolated language impairment as the primary presentation of sporadic Creutzfeldt Jakob Disease
"We described a series of patients with sCJD presenting with isolated language impairment."
https://onlinelibrary.wiley.com/doi/10.1111/ane.12600
https://archive.ph/uPYnc
18 September 2015
Unilateral Creutzfeldt-Jakob Disease Presenting as Rapidly Progressive Aphasia
"A 64-year-old man presented with a three day history of progressive Broca’s aphasia, followed within 3 weeks by exclusively right-sided myoclonus, rigidity, and dystonia. Within 4 weeks he was globally aphasie. He died within 7 weeks of onset."
https://www.cambridge.org/core/journals/canadian-journal-of-neurological-sciences/article/unilateral-creutzfeldtjakob-disease-presenting-as-rapidly-progressive-aphasia/C2F42E8BA79A666F774131FDFDFD00CB
https://archive.ph/vSDnT
January 01, 1989
Creutzfeldt‐Jakob disease presenting as isolated aphasia
"We report a 61-year-old man with autopsy-proven Creutzfeldt-Jakob disease (CJD) whose major initial manifestation was a progressive, fluent aphasia."
https://n.neurology.org/content/39/1/55
https://archive.ph/xXXph
December 9, 2005
Study Links Progressive Aphasia Syndrome To Prion Gene
"Most people with a rare type of dementia called primary progressive aphasia (PPA) have a specific combination of prion gene variants, a new study shows. The study is the first to link the prion protein gene to this disorder."
https://www.sciencedaily.com/releases/2005/12/051209175822.htm
https://archive.ph/a3aC7
2018 Jan 5
The language disorder of prion disease is characteristic of a dynamic aphasia and is rarely an isolated clinical feature
"These results provide evidence that the language disorder in prion disease is rarely an isolated clinical or cognitive feature. The language abnormality is indicative of a dynamic aphasia in the context of a prominent dysexecutive syndrome, similar to that seen in patients with the degenerative movement disorder progressive supranuclear palsy (PSP)."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755885/
https://archive.ph/EfGWx
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755885/pdf/pone.0190818.pdf
https://web.archive.org/save/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5755885/pdf/pone.0190818.pdf
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0190818
https://archive.ph/MzdyZ