Anonymous ID: 4d1d67 April 14, 2022, 5:57 a.m. No.16074178   🗄️.is 🔗kun   >>4265

>>16074099 (lb)

>slide.

what do you mean by 'slide'? we have unlimited bred to share and connect info. if the content is not of interest to (you), you are just one individual who can ignore or filter. continuing to comment on something that you consider bullshit is strange, glowie, and gives more attention to that which you are calling bullshit. carry on.

 

just like showbiz/sport/medea, hate/love are the same thing: your energy given away to something else. why bother on 'bullshit'? rhetorical. you have already established yourpatternfor those of us who see. Kek!

Anonymous ID: 4d1d67 April 14, 2022, 6:03 a.m. No.16074215   🗄️.is 🔗kun   >>4230 >>4255 >>4371

>>16074170

board must act in the best interest of the shareholders. A boards failure to uphold their fiduciary responsibility to the shareholders can result in CRIMINAL liability and responsibility.

 

twitter is publicly traded with shares owned by millions.

 

https://www.investopedia.com/ask/answers/05/shareholderinterest.asp

 

consider trial of Kenneth Lay, former chairman and CEO of Enron, and Jeffrey Skilling, former CEO and COO, presided over by federal district court Judge Sim Lake in 2006 in response to the Enron scandal.

Anonymous ID: 4d1d67 April 14, 2022, 6:36 a.m. No.16074356   🗄️.is 🔗kun   >>4358 >>4368

>>16074230

indeed. it is also why nearly ALL publicly traded consumer manufacturing, etc is done in countries with child and slave labor, (or with actual prison slave labor here), as it is 'legal', and the best option for the bottom line to the boards.

Anonymous ID: 4d1d67 April 14, 2022, 6:36 a.m. No.16074358   🗄️.is 🔗kun   >>4359 >>4368 >>4381

>>16074356

> actual prison slave labor

>>16074230

 

"If you look for the 'made in America' tag, you may want to make sure you are not supporting slave labor first.

 

Most stuff labeled 'made in america' is made off of the slave labor in the US prison industrial complex.

 

Including products from Microsoft, Nike, Nintendo, Honda, Pfizer, Saks Fifth Avenue, JCPenney, Macy’s, Starbucks, Victoria's Secret, Chrysler, Ford, GM, K Mart, and more.

 

Wal Mart produce is farmed by prison labor.

Martori Farms: Abusive Conditions at a Key Wal-Mart Supplier 

http://www.truth-out.org/index.php?option=com_k2&view=item&id=1808:martori-farms-abusive-conditions-at-a-key-walmart-supplier

 

Tesla CEO’s Company Used Prison Labor to Build Taxpayer-Subsidized Solar Panels

http://usuncut.com/class-war/elon-musks-solarcity-exploits-prison-labor-manufacture-taxpayer-subsidized-solar-panels/

 

Identifying Businesses That Profit From Prison Labor

https://www.popularresistance.org/identifying-businesses-that-profit-from-prison-labor/

 

BANKS: American General Financial Group, American Express Company, Bank of America, Community Financial Services Corporation, Credit Card Coalition, Credit Union National Association, Inc., Fidelity Inestments, Harris Trust & Savings Bank, Household International, LaSalle National Bank, J.P. Morgan & Company, Non-Bank Funds Transmitters Group

 

ENERGY PRODUCERS/OIL: American Petroleum Institute, Amoco Corporation, ARCO, BP America, Inc., Caltex Petroleum, Chevron Corporation, ExxonMobil Corporation, Mobil Oil Corporation, Phillips Petroleum Company.

 

ENERGY PRODUCERS/UTILITIES: American Electric Power Association, American Gas Association, Center for Energy and Economic Development, Commonwealth Edison Company, Consolidated Edison Company of New York, Inc., Edison Electric Institute, Independent Power Producers of New York, Koch Industries, Inc., Mid-American Energy Company, Natural Gas Supply Association, PG&E Corporation/PG&E National Energy Group, U.S. Generating Company.

 

pt 1

Anonymous ID: 4d1d67 April 14, 2022, 6:36 a.m. No.16074359   🗄️.is 🔗kun   >>4368

>>16074358

INSURANCE: Alliance of American Insurers, Allstate Insurance Company, American Council of Life Insurance, American Insurance Association, Blue Cross and Blue Shield Corporation, Coalition for Asbestos Justice, (This organization was formed in October 2000 to explore new judicial approaches to asbestos litigation.” Its members include ACE-USA, Chubb & Son, CNA service mark companies, Fireman’s Fund Insurance Company, Hartford Financial Services Group, Inc., Kemper Insurance Companies, Liberty Mutual Insurance Group, and St. Paul Fire and Marine Insurance Company. Counsel to the coalition is Victor E. Schwartz of the law firm of Crowell & Moring in Washington, D.C., a longtime ALEC ally.)

Fortis Health, GEICO, Golden Rule Insurance Company, Guarantee Trust Life Insurance, MEGA Life and Health Insurance Company, National Association of Independent Insurers, Nationwide Insurance/National Financial, State Farm Insurance Companies, Wausau Insurance Companies, Zurich Insurance.

 

PHARMACEUTICALS: Abbott Laboratories, Aventis Pharmaceuticals, Inc., Bayer Corporation, Eli Lilly & Company, GlaxoSmithKline, Glaxo Wellcome, Inc., Hoffman-LaRoche, Inc., Merck & Company, Inc., Pfizer, Inc., Pharmaceutical Research and Manufacturers of

America (PhRMA), Pharmacia Corporation, Rhone-Poulenc Rorer, Inc., Schering-Plough Corporation, Smith, Kline & French, WYETH, a division of American Home Products Corporation.

 

MANUFACTURING:American Plastics Council, Archer Daniels Midland Corporation, AutoZone, Inc. (aftermarket automotive parts), Cargill, Inc., Caterpillar, Inc., Chlorine Chemistry Council, Deere & Company, Fruit of the Loom, Grocery Manufacturers of America, Inland Steel Industries, Inc., International Game Technology, International Paper, Johnson & Johnson, Keystone Automotive Industries, Motorola, Inc., Procter & Gamble, Sara Lee Corporation.

 

TELECOMMUNICATIONS: AT&T, Ameritech, BellSouth Telecommunications, Inc., GTE Corporation, MCI, National Cable and Telecommunications Association, SBC Communications, Inc., Sprint, UST Public Affairs, Inc., Verizon Communications, Inc.

 

TRANSPORTATION: Air Transport Association of America, American Trucking Association, The Boeing Company, United Airlines, United Parcel Service (UPS).

 

OTHER U.S. COMPANIES: Amway Corporation, Cabot Sedgewick, Cendant Corporation, Corrections Corporation of America, Dresser Industries, Federated Department Stores, International Gold Corporation, Mary Kay Cosmetics, Microsoft Corporation, Newmont Mining Corporation, Quaker Oats, Sears, Roebuck & Company, Service Corporation International, Taxpayers Network, Inc., Turner Construction, Wal-Mart Stores, Inc.

 

ORGANIZATIONS/ASSOCIATIONS: Adolph Coors Foundation, Ameritech Foundation, Bell & Howell Foundation, Carthage Foundation, Charles G. Koch Charitable Foundation, ELW Foundation, Grocery Manufacturers of America, Heartland Institute of Chicago, The Heritage Foundation, Iowans for Tax Relief, Lynde and Harry Bradley Foundation of Milwaukee, National Pork Producers Association, National Rifle Association, Olin Foundation, Roe Foundation, Scaiffe Foundation, Shell Oil Company Foundation, Smith Richardson Foundation, Steel Recycling Institute, Tax Education Support Organization, Texas Educational Foundation, UPS Foundation.

 

13 Mainstream Corporations Benefiting from the Prison Industrial Complex

http://atlantablackstar.com/2014/10/10/12-mainstream-corporations-benefiting-from-the-prison-industrial-complex/

 

What Do Prisoners Make for Victoria's Secret?

http://www.motherjones.com/politics/2008/07/what-do-prisoners-make-victorias-secret

 

Whole Foods to Drop Products Made by Inmates in Prison Labor Program by April 2016

http://www.nbcnews.com/business/business-news/whole-foods-drop-products-made-inmates-prison-labor-program-n436821

 

http://www.buycott.com/campaign/companies/504/boycott-companies-that-utilise-prison-labour

 

____

In America, a large percentage of the prison population exists due to mandatory sentencing (which coincided with the rise of the private prison industry, as well as the advent of so-called 'gangsta rap'- a creation of both private prison executives and record label executives), three strikes laws, and treating addiction as a criminal offense.

 

Drug addicts, by the very nature of their illness, are existing illegally, by way of what they possess, and by what is in their system at any given time.

 

So now, we have a system which perpetuates 'criminal' illness, then preys upon it by enslaving it for profit.

 

Quite the loosh farm, within a loosh farm.

 

pt 2

Anonymous ID: 4d1d67 April 14, 2022, 6:38 a.m. No.16074368   🗄️.is 🔗kun   >>4383

>>16074230

>>16074358

>>16074356

>>16074359

 

"Tens of thousands of Americans are paid far below the minimum wage, sometimes less than a dollar for an hour's work — and it's totally legal and constitutional.

 

How? Because the work takes place in prison.

 

UNICOR, a government-owned company that uses federal prison labor, pays workers anywhere between 23 cents and $1.15 an hour. And it has a lot of employees: In 2007, the Congressional Research Service estimated that 19,720 federal inmates — about 18 percent of the federal prison population — work for UNICOR."

 

"But cheap prison labor can also hurt workers who aren't in prison. Since prisoners are paid so little — far below the minimum wage — they are a much cheaper option for private companies and government contracts.

 

Factory owners, for example, have complained that they can't compete with UNICOR in bids for government contracts. "We pay employees $9 on average. They get full medical insurance, 401(k) plans, and paid vacation," Kurt Wilson, an American Apparel executive, told CNN Money in 2012. "Yet we're competing against a federal program that doesn't pay any of that.""

 

http://www.vox.com/2015/9/7/9262649/prison-labor-wages

 

The following is from

The Massive Prison Industry In The United States: Big Business & Slavery

http://www.transients.info/2015/12/the-massive-prison-industry-in-united.html?m=1

“Prison labor based in private prisons is a multimillion-dollar industry with its own trade exhibitions, conventions, websites, and mail-order/Internet catalogs (Pelaez 2008). . . . The industry also has direct advertising campaigns, architecture companies, construction companies, investment houses on Wall Street, plumbing supply companies, food supply companies, armed security, and padded cell manufacturing, all of which rival those of any other private industry (Pelaez 2008). Furthermore, private prisoners at the state level produce a variety of goods and services, from clothing to toys to telemarketing and customer service (Erlich 2005). The private federal prison industry also produces nearly all military goods, from uniform helmet to ammunition, along with durable goods ranging from paint to office furniture (Pelaez 2008).” (Prison Privatization: The Many Facets of a Controversial Industry, Volume 1 edited by Byron Eugene Price, John Charles)

 

“Prison labor has its roots in slavery. After the 1861-1865 Civil War, a system of ‘hiring out prisoners’ was introduced in order to continue the slavery tradition. Freed slaves were charged with not carrying out their sharecropping commitments (cultivating someone else’s land in exchange for part of the harvest) or petty thievery – which were almost never proven – and were then ‘hired out’ for cotton picking, working in mines and building railroads. From 1870 until 1910 in the state of Georgia, 88% of hired-out convicts were Black. In Alabama, 93% of ‘hired-out’miners were Black. In Mississippi, a huge prison farm similar to the old slave plantations replaced the system of hiring out convicts. The notorious Parchman plantation existed until 1972.” http://www.globalresearch.ca/the-prison-industry-in-the-united-states-big-business-or-a-new-form-of-slavery/8289

 

As stated earlier, it appears that the prison 'labor/slave' system is the micro reflection/echo, of the earth labor/taxation/loosh farm/plantation system, the macro version.

 

"…America has four percent of the world’s population, yet still carries approximately twenty five percent of the world’s prison population? That is a staggering number. America has the highest incarceration rate in the world and it is increasing exponentially each year. Almost half of American juveniles will have been arrested before they reach their 23rd birthday…"

 

Made in America.

 

pt 3

Anonymous ID: 4d1d67 April 14, 2022, 6:41 a.m. No.16074383   🗄️.is 🔗kun   >>4385

>>16074368

and then there is the entire industry of prison slavery and how it was marketed & created….

 

https://www.hiphopisread.com/2012/04/secret-meeting-that-changed-rap-music.html

 

SECRET MEETING THAT CHANGED HIP HOP

 

Hello,

 

After more than 20 years, I’ve finally decided to tell the world what I witnessed in 1991, which I believe was one of the biggest turning point in popular music, and ultimately American society. I have struggled for a long time weighing the pros and cons of making this story public as I was reluctant to implicate the individuals who were present that day. So I’ve simply decided to leave out names and all the details that may risk my personal well being and that of those who were, like me, dragged into something they weren’t ready for.

 

Between the late 80’s and early 90’s, I was what you may call a “decision maker” with one of the more established company in the music industry. I came from Europe in the early 80’s and quickly established myself in the business. The industry was different back then. Since technology and media weren’t accessible to people like they are today, the industry had more control over the public and had the means to influence them anyway it wanted. This may explain why in early 1991, I was invited to attend a closed door meeting with a small group of music business insiders to discuss rap music’s new direction. Little did I know that we would be asked to participate in one of the most unethical and destructive business practice I’ve ever seen.

 

pt 1

Anonymous ID: 4d1d67 April 14, 2022, 6:42 a.m. No.16074385   🗄️.is 🔗kun   >>4388

>>16074383

The meeting was held at a private residence on the outskirts of Los Angeles. I remember about 25 to 30 people being there, most of them familiar faces. Speaking to those I knew, we joked about the theme of the meeting as many of us did not care for rap music and failed to see the purpose of being invited to a private gathering to discuss its future. Among the attendees was a small group of unfamiliar faces who stayed to themselves and made no attempt to socialize beyond their circle. Based on their behavior and formal appearances, they didn’t seem to be in our industry. Our casual chatter was interrupted when we were asked to sign a confidentiality agreement preventing us from publicly discussing the information presented during the meeting. Needless to say, this intrigued and in some cases disturbed many of us. The agreement was only a page long but very clear on the matter and consequences which stated that violating the terms would result in job termination. We asked several people what this meeting was about and the reason for such secrecy but couldn’t find anyone who had answers for us. A few people refused to sign and walked out. No one stopped them. I was tempted to follow but curiosity got the best of me. A man who was part of the “unfamiliar” group collected the agreements from us.

 

Quickly after the meeting began, one of my industry colleagues (who shall remain nameless like everyone else) thanked us for attending. He then gave the floor to a man who only introduced himself by first name and gave no further details about his personal background. I think he was the owner of the residence but it was never confirmed. He briefly praised all of us for the success we had achieved in our industry and congratulated us for being selected as part of this small group of “decision makers”. At this point I begin to feel slightly uncomfortable at the strangeness of this gathering. The subject quickly changed as the speaker went on to tell us that the respective companies we represented had invested in a very profitable industry which could become even more rewarding with our active involvement. He explained that the companies we work for had invested millions into the building of privately owned prisons and that our positions of influence in the music industry would actually impact the profitability of these investments. I remember many of us in the group immediately looking at each other in confusion. At the time, I didn’t know what a private prison was but I wasn’t the only one. Sure enough, someone asked what these prisons were and what any of this had to do with us. We were told that these prisons were built by privately owned companies who received funding from the government based on the number of inmates. The more inmates, the more money the government would pay these prisons. It was also made clear to us that since these prisons are privately owned, as they become publicly traded, we’d be able to buy shares. Most of us were taken back by this. Again, a couple of people asked what this had to do with us. At this point, my industry colleague who had first opened the meeting took the floor again and answered our questions. He told us that since our employers had become silent investors in this prison business, it was now in their interest to make sure that these prisons remained filled. Our job would be to help make this happen by marketing music which promotes criminal behavior, rap being the music of choice. He assured us that this would be a great situation for us because rap music was becoming an increasingly profitable market for our companies, and as employee, we’d also be able to buy personal stocks in these prisons. Immediately, silence came over the room. You could have heard a pin drop. I remember looking around to make sure I wasn’t dreaming and saw half of the people with dropped jaws. My daze was interrupted when someone shouted, “Is this a f** joke?” At this point things became chaotic. Two of the men who were part of the “unfamiliar” group grabbed the man who shouted out and attempted to remove him from the house. A few of us, myself included, tried to intervene. One of them pulled out a gun and we all backed off. They separated us from the crowd and all four of us were escorted outside. My industry colleague who had opened the meeting earlier hurried out to meet us and reminded us that we had signed agreement and would suffer the consequences of speaking about this publicly or even with those who attended the meeting. I asked him why he was involved with something this corrupt and he replied that it was bigger than the music business and nothing we’d want to challenge without risking consequences. We all protested and as he walked back into the house I remember word for word the last thing he said, “It’s out of my hands now. Remember you signed an agreement.” He then closed the door behind him. The men rushed us to our cars and actually watched until we drove off.

 

pt 2

Anonymous ID: 4d1d67 April 14, 2022, 6:42 a.m. No.16074388   🗄️.is 🔗kun   >>4391

>>16074385

A million things were going through my mind as I drove away and I eventually decided to pull over and park on a side street in order to collect my thoughts. I replayed everything in my mind repeatedly and it all seemed very surreal to me. I was angry with myself for not having taken a more active role in questioning what had been presented to us. I’d like to believe the shock of it all is what suspended my better nature. After what seemed like an eternity, I was able to calm myself enough to make it home. I didn’t talk or call anyone that night. The next day back at the office, I was visibly out of it but blamed it on being under the weather. No one else in my department had been invited to the meeting and I felt a sense of guilt for not being able to share what I had witnessed. I thought about contacting the 3 others who wear kicked out of the house but I didn’t remember their names and thought that tracking them down would probably bring unwanted attention. I considered speaking out publicly at the risk of losing my job but I realized I’d probably be jeopardizing more than my job and I wasn’t willing to risk anything happening to my family. I thought about those men with guns and wondered who they were? I had been told that this was bigger than the music business and all I could do was let my imagination run free. There were no answers and no one to talk to. I tried to do a little bit of research on private prisons but didn’t uncover anything about the music business’ involvement. However, the information I did find confirmed how dangerous this prison business really was. Days turned into weeks and weeks into months. Eventually, it was as if the meeting had never taken place. It all seemed surreal. I became more reclusive and stopped going to any industry events unless professionally obligated to do so. On two occasions, I found myself attending the same function as my former colleague. Both times, our eyes met but nothing more was exchanged.

 

As the months passed, rap music had definitely changed direction. I was never a fan of it but even I could tell the difference. Rap acts that talked about politics or harmless fun were quickly fading away as gangster rap started dominating the airwaves. Only a few months had passed since the meeting but I suspect that the ideas presented that day had been successfully implemented. It was as if the order has been given to all major label executives. The music was climbing the charts and most companies when more than happy to capitalize on it. Each one was churning out their very own gangster rap acts on an assembly line. Everyone bought into it, consumers included. Violence and drug use became a central theme in most rap music. I spoke to a few of my peers in the industry to get their opinions on the new trend but was told repeatedly that it was all about supply and demand. Sadly many of them even expressed that the music reinforced their prejudice of minorities.

 

pt 3

Anonymous ID: 4d1d67 April 14, 2022, 6:42 a.m. No.16074391   🗄️.is 🔗kun   >>4457 >>4773

>>16074388

I officially quit the music business in 1993 but my heart had already left months before. I broke ties with the majority of my peers and removed myself from this thing I had once loved. I took some time off, returned to Europe for a few years, settled out of state, and lived a “quiet” life away from the world of entertainment. As the years passed, I managed to keep my secret, fearful of sharing it with the wrong person but also a little ashamed of not having had the balls to blow the whistle. But as rap got worse, my guilt grew. Fortunately, in the late 90’s, having the internet as a resource which wasn’t at my disposal in the early days made it easier for me to investigate what is now labeled the prison industrial complex. Now that I have a greater understanding of how private prisons operate, things make much more sense than they ever have. I see how the criminalization of rap music played a big part in promoting racial stereotypes and misguided so many impressionable young minds into adopting these glorified criminal behaviors which often lead to incarceration. Twenty years of guilt is a heavy load to carry but the least I can do now is to share my story, hoping that fans of rap music realize how they’ve been used for the past 2 decades. Although I plan on remaining anonymous for obvious reasons, my goal now is to get this information out to as many people as possible. Please help me spread the word. Hopefully, others who attended the meeting back in 1991 will be inspired by this and tell their own stories. Most importantly, if only one life has been touched by my story, I pray it makes the weight of my guilt a little more tolerable.

 

Thank you.

 

pt 4 of 4

Anonymous ID: 4d1d67 April 14, 2022, 6:47 a.m. No.16074414   🗄️.is 🔗kun

>>16074255

>the best interests of the share holders.

is making them money. FIDUCIARYresponsibility. An fair, legal offer above current valuation is exactly that. A clear interest garnering opportunity for the shareholders… to make more than their holdings are valued.

 

"A fiduciary’s responsibilities include:

acting solely in the interest of the participants and their beneficiaries;"- irs.gov

Anonymous ID: 4d1d67 April 14, 2022, 6:53 a.m. No.16074453   🗄️.is 🔗kun

>>16074436

call it what you like. It is the legal fiduciary responsibility of the board. And carries criminal liabilities when failed or negligent.

 

"Ahostile takeoveris when one company acquires another without the consent of the target company’s leadership. A hostile takeover usually takes the form of a tender offer, where the hostile bidder offers to buy shares directly from shareholders, usually at apremium price."

Anonymous ID: 4d1d67 April 14, 2022, 7:09 a.m. No.16074545   🗄️.is 🔗kun   >>4566

>>16074515

another venom/corona connection…

 

OCTOBER 25, 2021

 

Scorpion sting might save lives from coronavirus

 

https://medicalxpress.com/news/2021-10-scorpion-coronavirus.html

 

The potential of scorpion venoms to combat the threat of new variants of coronavirus is being explored by scientists from the University of Aberdeen and the University of Suez Canal, Egypt.

 

Scorpions are one of the oldest animals on Earth, having existed for more than 400 million years. Their venoms have been used in traditional therapies since antiquity in many countries, particularly in China and India.

 

Scorpion venoms contain a "fascinating cocktail" of biologically active peptides, many of which are very potent neurotoxins, while several have shown strong antibacterial and antiviral activities and are thought to play a role in protecting the venomous gland from microbial infection.

 

These peptides could serve as a good starting point to design novel anti-coronavirus drugs.

 

Collection of scorpion species were carried out under the tenets of the Convention on Biological Diversity and following the Nagoya Protocol on Access to Genetic Resources and the Fair and Equitable Sharing of Benefits Arising from their Utilization and the relevant legislations. After milking their venoms, scorpions were released into their natural habitats in the Egyptian Desert.

 

A venomous gland from each species was collected to analyze its genetic material which will reveal copious amounts of useful information on the venom peptide composition.

 

Scorpion venom is a very complex mixture containing hundreds of toxins and their analysis entails laborious experiments. After their purification and identification, venom peptides will be synthesized in higher quantities and structurally modified to confer drug-like properties using tailoring enzymes in the laboratory of Dr. Houssen.

 

Dr. Houssen said: "The study of scorpion venoms as a source of novel drugs is an exciting and productive area worthy of further investigation.

 

"We have already seen that these venoms contain extremely potent bioactive peptides, and we believe that there are many more await discovery."

 

Professor Abdel-Rahman said: "Several scorpion species including the most toxic in the world are widespread in Egypt.

 

"Their venoms have not yet been fully studied and may represent an unorthodox source of new medicines."

Anonymous ID: 4d1d67 April 14, 2022, 7:12 a.m. No.16074566   🗄️.is 🔗kun   >>4624 >>4631 >>4701 >>4711 >>4836

>>16074545

Examining the interactions scorpion venom peptides (HP1090, Meucin-13, and Meucin-18) with the receptor binding domain of the coronavirus spike protein to design a mutated therapeutic peptide

 

J Mol Graph Model

. 2021 Sep;107:107952. doi: 10.1016/j.jmgm.2021.107952. Epub 2021 Jun 3.

 

https://pubmed.ncbi.nlm.nih.gov/34119951/

 

bstract

The spike protein of SARS-CoV-2 (Severe Acute Respiratory Syndrome coronavirus 2) interacts with the ACE2 receptor in human cells and starts the infection of COVID-19 disease. Given the importance of spike protein's interaction with ACE2 receptor, we selected some antiviral peptides of venom scorpion such as HP1090, meucin-13, and meucin-18 and performed docking and molecular docking analysis of them with the RBD domain of spike protein. The results showed that meucin-18 (FFGHLFKLATKIIPSLFQ) had better interaction with the RBD domain of spike protein than other peptides. We also designed some mutations in meucin-18 and investigated their interactions with the RBD domain. The results revealed that the A9T mutation had more effective interaction with the RBD domain than the meucin-18 and was able to inhibit spike protein's interaction with ACE2 receptor. Hence, peptide "FFGHLFKLTTKIIPSLFQ" can be considered as the potential drug for the treatment of COVID-19 disease.

 

Medolife's Therapeutic Scorpion Peptide Proves Successful in Treating COVID-19 Patients in Dominican Republic Study

 

https://www.accesswire.com/626095/Medolifes-Therapeutic-Scorpion-Peptide-Proves-Successful-in-Treating-COVID-19-Patients-in-Dominican-Republic-Study

Anonymous ID: 4d1d67 April 14, 2022, 7:30 a.m. No.16074693   🗄️.is 🔗kun   >>4711 >>4715 >>4836

>>16074631

https://aapep.bocsci.com/product/antimicrobial-peptide-meucin-18-1-precursor-365615.html

 

Mesobuthus eupeus, the lesser Asian scorpion or the mottled scorpion.

"Venom

The venom of M. eupeus is not as potent as that of other dangerous buthid species.[citation needed] Victims of stings feel intense pain, hyperemia, swelling and a burning sensation in the affected area, while numbness and itching were also reported in some cases.[8]

 

As in other scorpions, the venom of M. eupeus contains various neurotoxic proteins that interact specifically with ion channels. A number of unique proteins in this scorpion's venom have been identified,[9] cloned and investigated for clinical applications. For instance, MeuKTX, structurally related to BmKTX (α-KTx3.6) from M. martensii, potently inhibits rKv1.1, rKv1.2 and hKv1.3 channels but does not affect rKv1.4, rKv1.5, hKv3.1, rKv4.3, and hERG channels even at high concentrations.[10] In contrast, BeKm-1 specifically inhibits hERG channels,[11] which are potassium channels critical to maintaining normal electrical activities in the heart,[12] but showed no effects on various other potassium channels tested.[11] Inhibitors of sodium channels have also been found in this venom.[13][14] MeuNaTxa-12 and MeuNaTxa-13 can affect cloned mammalian Nav subtypes rNav1.1, rNav1.2, rNav1.4 and mNav1.6, but not rNav1.5. In vivo assays showed that these two toxins have potential to be insecticidal agents, with MeuNaTxa-12 having 5-fold higher toxicity than MeuNaTxa-13.[15]

 

A number of antimicrobial peptides have also been found in the venom of M. eupeus. Meucin-13 and Meucin-18 exhibited extensive cytolytic effects on bacteria, fungi and yeasts.[16] Furthermore, Meucin-24 and Meucin-25, first identified from genetic sequences expressed in their venom gland, were shown to selectively kill Plasmodium falciparum and inhibit the development of Plasmodium berghei, both malaria parasites, but do not harm mammalian cells. These two venom-derived proteins are therefore attractive candidates for the development of anti-malarial drugs"