Anonymous ID: d0d110 Dec. 6, 2022, 9:56 a.m. No.17889914   🗄️.is 🔗kun

Reevaluation of antibody-dependent enhancement of infection in anti-SARS-CoV-2 therapeutic antibodies and mRNA-vaccine antisera using FcR- and ACE2-positive cells

 

https://www.nature.com/articles/s41598-022-19993-w#Sec4

 

Abstract

Many therapeutic antibodies (Abs) and mRNA vaccines, both targeting SARS-CoV-2 spike protein (S-protein), have been developed and approved in order to combat the ongoing COVID-19 pandemic. In consideration of these developments, a common concern has been the potential for Ab-dependent enhancement (ADE) of infection caused by inoculated or induced Abs. Although the preventive and therapeutic effects of these Abs are obvious, little attention has been paid to the influence of the remaining and dwindling anti-S-protein Abs in vivo. Here, we demonstrate that certain monoclonal Abs (mAbs) approved as therapeutic neutralizing anti-S-protein mAbs for human usage have the potential to cause ADE in a narrow range of Ab concentrations. Although sera collected from mRNA-vaccinated individuals exhibited neutralizing activity, some sera gradually exhibited dominance of ADE activity in a time-dependent manner. None of the sera examined exhibited neutralizing activity against infection with the Omicron strain. Rather, some ADE of Omicron infection was observed in some sera. These results suggest the possible emergence of adverse effects caused by these Abs in addition to the therapeutic or preventive effect.

Anonymous ID: d0d110 Dec. 6, 2022, 9:57 a.m. No.17890183   🗄️.is 🔗kun   >>0656 >>0891 >>1010

Greg Abbott

@GregAbbott_TX

Texas is the research & innovation capital of the United States.

 

The University of Houston's fentanyl vaccine development research will help Texas continue to lead the fight against this deadly drug.

 

Texas innovation saves lives.

 

https://mobile.twitter.com/GregAbbott_TX/status/1599953608367185920

Anonymous ID: d0d110 Dec. 6, 2022, 10:16 a.m. No.17892808   🗄️.is 🔗kun

>>17891010

not when giving to everybody as a 'protective mea$ure' to protect against 'acccidental' or unknowing exposure.

 

food, meds, bandages, etc all possible delivery vectors, and last two made mostly in China