>DOUGH
https://apnews.com/article/greece-train-crash-athens-deadly-accident-ce2d6d2f643deaf7afb389d290b597a4
Greek stationmaster arrested in head-on train crash; 36 dead
https://apnews.com/article/covid-misinformation-china-lab-leak-coronavirus-4a76f8196d7c504f288429d1018d2990
COVID-19 conspiracies soar after latest report on origins
COVID-19′s origins remain hazy. Three years after the start of the pandemic, it’s still unclear whether the coronavirus that causes the disease leaked from a lab or spread to humans from an animal.
This much is known: When it comes to COVID-19 misinformation, any new report on the virus’ origin quickly triggers a relapse and a return of misleading claims about the virus, vaccines and masks that have reverberated since the pandemic began.
It happened again this week after the Energy Department confirmed that a classified report determined, with low confidence, that the virus escaped from a lab. Within hours, online mentions of conspiracy theories involving COVID-19 began to rise, with many commenters saying the classified report was proof they were right all along.
Far from definitive, the Energy Department’s report is the latest of many attempts by scientists and officials to identify the origin of the virus, which has now killed nearly 7 million people after being first detected in the central Chinese city of Wuhan in late 2019.
The report has not been made public, and officials in Washington stressed that a variety of U.S. agencies are not in agreement on the origin. On Tuesday, FBI Director Christopher Wray told Fox News that the FBI “has for quite some time now” assessed that the pandemic’s origins are “most likely a potential lab incident in Wuhan.”
look how seriously they take all of this, by finishing the article with;
>“BREAKING,” a pro-China YouTuber wrote on Twitter. “I can now announce, with ‘low confidence,’ that the COVID pandemic began as a leak from Hunter Biden’s laptop.”
https://apnews.com/article/health-social-media-boston-7a6bed81a86fe5576ca0145d893ad153
Children’s hospitals harassed over transgender care programs
https://apnews.com/article/elizabeth-holmes-gives-birth-a0baf297ce677e262a92a82f92368054
Elizabeth Holmes has 2nd child as she tries to avoid prison
https://twitter.com/laura_ungar
https://apnews.com/article/science-biology-hong-kong-united-kingdom-health-0396b63f8550d2c9c46ff77965035f46
For man behind gene-edited babies, a rocky return to science
Five years ago, scientist He Jiankui shocked his peers and the world with claims that he created the first genetically edited babies. Now, after serving three years in a Chinese prison for practicing medicine without a license, he faces obstacles and critics as he tries to re-enter science.
https://twitter.com/AP/status/1618006305993523200
Rylae-Ann Poulin was among the first to receive gene therapy directly to her brain to treat a rare genetic disease, an approach scientists say holds promise for treating a host of brain disorders.
https://apnews.com/article/taiwan-health-ohio-europe-gene-therapy-79c0b20862f3f9e2bb4ee977c050489d
Promising gene therapy delivers treatment directly to brain
Her treatment recently became the first brain-delivered gene therapy after its approval in Europe and the United Kingdom for AADC deficiency, a disorder that interferes with the way cells in the nervous system communicate. New Jersey drugmaker PTC Therapeutics plans to seek U.S. approval this year.
About 30 U.S. studies testing gene therapy to the brain for various disorders are ongoing, according to the National Institutes of Health. One, led by Dr. Krystof Bankiewicz at Ohio State University, also targets AADC deficiency. Others test treatments for disorders such as Alzheimer’s, Parkinson’s and Huntington’s.
Around that time, Wei’s brother sent her a Facebook post about a child in Taiwan with AADC deficiency. The extremely rare disorder afflicts about 135 children worldwide, many in that country. Wei, who was born in Taiwan, and her husband, Richard Poulin III, sought out a doctor there who correctly diagnosed Rylae-Ann. They learned she could qualify for a gene therapy clinical trial in Taiwan.
https://twitter.com/atrupar
A more practical hurdle is cost. The price of gene therapies, borne mostly by insurers and governments, can run into the millions. The one-time PTC therapy, called Upstaza, costs more than $3 million in Europe, for example.
https://en.wikipedia.org/wiki/Eladocagene_exuparvovec
Eladocagene exuparvovec is an experimental gene therapy product for the treatment of aromatic L‑amino acid decarboxylase (AADC) deficiency. It infuses the gene encoding for the human AADC enzyme into the putamen region of the brain. The subsequent expression of AADC results in dopamine production and, as a result, development of motor function in patients with AADC deficiency.
The most common side effects include initial insomnia, irritability and dyskinesia.
As of May 2022, eladocagene exuparvovec is recommended for approval by the European Commission.
https://www.ptcbio.com/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8822132/
delivered to cells within the putamen
https://en.wikipedia.org/wiki/Putamen
>delivered to cells within the putamen
>we only injected to the putamen
Do you think they went in via eyeball socket?
That would probably leave a black eye.
>gene therapies
>makes his forecasts based on the motions of celestial bodies
>convergence of critical planetary geometry