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https://www.nature.com/articles/d41586-023-02627-0
Audio long read: Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?
Investigations suggest that, in some fields, at least one-quarter of clinical trials might be problematic or even entirely made up. Faked or unreliable trials are dangerous, as they could end up being included in the reviews that help inform clinical treatments. However, the extent of the problem in unclear, and many researchers urge stronger scrutiny.
This is an audio version of our Feature: Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?
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doi: https://doi.org/10.1038/d41586-023-02627-0
https://www.youtube.com/watch?v=_QLvzCr6nz4
https://www.tandfonline.com/doi/full/10.1080/08916934.2023.2229072
The onset of de novo autoantibodies in healthcare workers after mRNA based anti-SARS-CoV-2 vaccines: a single centre prospective follow-up study
Abstract
Nowadays, data concerning the risk of autoimmune disease after SARS-CoV-2 (COVID-19) vaccination is controversial. The aim of this single centre prospective follow-up study was to evaluate whether healthcare workers (HCWs) vaccinated with BNT162b2 mRNA and mRNA-1273 will show a development and/or a persistence of autoantibodies, focussing on the detection of antibodies against nuclear antigens (antinuclear antibodies, ANA). We enrolled 155 HCWs, however only 108 of them received the third dose and were considered for further analysis. Blood samples were collected before vaccine inoculation (T0), at 3 (T1) and 12 months (T2) after the first dose. All samples were analysed for the presence of a) ANA using indirect Immunofluorescence [IIF] (dilutions of 1:80, 1:160. 1:320 and 1:640), and anti-smooth muscle antibodies (ASMA); b) anti-myeloperoxidase (anti-MPO), anti-proteinase 3 (anti-PR3) and anti-citrullinated peptide antibodies (aCCP) [FEIA]; c) anti-phospholipid antibodies (anticardiolipin [aCL], anti-beta-2- glycoprotein I [anti-ß-2GPI] (Chemiluminescence). Line-blot technology was performed using the following kit: EUROLINE ANA profile 3 plus DFS70 (IgG). Our research suggests that mRNA based anti-SARSCoV-2 vaccines can induce the production of de novo ANA in 22/77(28,57%) of subjects and that the percentage of positivity seems to be directly correlated to the number of vaccine expositions: 6/77 (7,79%) after 2 doses; 16/77 (20,78%) after 3 doses. Since it is known that hyperstimulation of the immune system could lead to autoimmunity, these preliminary results seem to further sustain the idea that the hyperstimulation of the immune system might lead to an autoinflammatory mechanism and eventually to autoimmune disorders. However, the link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated.
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ConclusionsIn conclusion, this study suggests that mRNA based anti-SARS-CoV-2 vaccines can induce the production of de novo ANA in 22/77(28,57%) of subjects and that the per-centage of positivity seems to be directly correlated to the number of vaccine exposures: 6/77 (7,79%) after 2 doses; 16/77 (20,78%) after 3 doses. As it is known that immune stimulation can act as a double-edged sword, meaning infec-tious and endogenous defense versus autoimmune related hyper-stimulation[55,56], our preliminary results and the presence of de novo ANA antibodies in HCWs seem to be more prone to sustain this second consequence: hyperstim-ulation. However, the link between SARS-CoV-2 vaccination and the development of autoimmune diseases needs to be further investigated.
Temporal association between COVID-19 vaccination and Raynaud's phenomenon: A case series
https://pubmed.ncbi.nlm.nih.gov/37067070/
Abstract
COVID-19 vaccine-related adverse events are mostly minor to moderate, and serious events are rare. Single cases of Raynaud's phenomenon (RP) in temporal proximity to COVID-19 vaccination have been reported. Demographic data, medical history, and detailed information regarding vaccination status and RP characteristics were obtained from patients with confirmed RP after COVID-19 vaccination. Fifteen participants reported the initial manifestation of RP, which occurred in 40% after the first, in 33% after the second, and in 27% after the third vaccination. RP development and occurrence of episodes were not linked to any specific vaccine type. New onset of disease was observed in 40% of the vaccinees after BNT162b2, in 33% after mRNA-1273, and in 27% after ChAdOx1 vaccination. Three out of four participants with preexisting RP prior to COVID-19 vaccination reported aggravation in frequency and intensity after immunization. Although COVID-19 vaccination is pivotal in controlling the pandemic,the observed temporal association between vaccine administration and RP occurrence warrants global activities to support pharmacovigilance for the detection of adverse reactions, one of which may include RP.
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.123.064772
Cardiovascular Assessment up to One Year After COVID-19 Vaccine–Associated Myocarditis
chrome is worth more than gold by the ounce.
BTW- Why does google/alphabet chrome browser use a qualcomm tool called adreno?
after up to one year post diagnosis of"COVID-19 vaccine-associated myocarditis"
56% myocarditis
54% abnormal T1 values
62 % abnormal T2 values
49% LGE
Disney Pixar. ALL satanic.
See the fire sacrifice programming in Toy Story, the missing toys= missing kids,, and being viewed by [them] as play things…
Man shoots through door at would-be burglars posing as maintenance workers: video
A Texas man opened fire on a pair of suspects who tried to break into his home over the weekend in a wild scene caught in doorbell footage.
One of the suspects, Aaron Contreras, knocked on the apartment door of Ethan Rodriguez on Saturday evening and claimed to be a maintenance worker there to check on the filters in his air conditioner, according to doorbell camera footage and an affidavit obtained by Fox Dallas.
Rodriguez, who was inside, answered the door via a digital doorbell app on his phone and claimed that no one was home, the video shows.
A few minutes later, Contreras came back with a handgun and attempted to kick down the front door to Rodriguez’s apartment, according to the clip.
A second man wearing a mask ran up the stairs and also tried to kick in the door, the footage shows.
Within moments, Rodriguez grabbed his gun and opened fire from inside his apartment through the front door — sending the men running.
The resident fired off several rounds and the video shows bullets striking the concrete wall across the way. Contreras fired two shots in response before he fled, according to the station.
https://nypost.com/2023/08/23/texas-man-shoots-through-door-at-would-be-burglars-posing-as-maintenance-workers/