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The Role of the Phosphorus Atom in Drug Design -
The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups.
>https://pubmed.ncbi.nlm.nih.gov/30536636/
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