[What could possibly go wrong….]
Report: Scientists Genetically Engineer Long-Extinct Dire Wolves
April 7, 2025
Scientists have reportedly genetically engineered dire wolves back into existence despite them being extinct for over 10,000 years.
A lengthy profile in TIME announced the scientific breakthrough on Monday with an expressed hope that the technology and methods used by Colossal Biosciences could potentially revive the woolly mammoth or preserve currently endangered species like the red wolf in North America or the quoll (a marsupial) in Australia.
The dire wolves went extinct in North America roughly 10,000 years ago from what scientists believe was the animal’s distinct hunting method of preying on larger animals as opposed to a more generalized hunting practice of smaller prey. According to Colossal’s chief scientist, Beth Shapiro, resurrecting the dire wolves involved taking blood cells from the living gray wolf and using gene editing technology (CRISPR) to genetically modify the cells in 20 different sites. This genetic material was then transferred to an egg cell from a domestic dog to create embryos that were then transferred to surrogates. The dire wolf pups gestated for 62 days with little complication before birth.
“We elected to put both pups with the surrogate who was displaying the best maternal instincts,” said Matt James, the company’s chief animal officer. “That reintroduction occurred just about two or so hours after birth, and she immediately began caring for them and allowing them to nurse.”
“The idea that we could just take a vial of blood, isolate EPCs, culture them, and clone from them, and they have a pretty high cloning efficiency, we think it’s a game changer,” said George Church, Colossal co-founder and professor of genetics at both Harvard University and the Massachusetts Institute of Technology (MIT).
The dire wolves have since been housed on a 2,000-acre ecological preserve at an undisclosed location somewhere in the United States.
“The 2,000 acres are surrounded by a 10-ft. fence and include a smaller six-acre site with a veterinary clinic, an extreme-weather shelter, and natural dens where the wolves can satisfy their innate desire for a secure retreat,” reported TIME. “A staff of veterinarians looks out for the animals around the clock.”
https://www.breitbart.com/pre-viral/2025/04/07/scientists-genetically-engineer-long-extinct-dire-wolves/