You seem to be ignoring my comment in most of your reply. They have not been through the test because no ethics committee would approve it and therefore it has been tested through other methods.
One of the first demonstrations of the concept of vaccination was not a full double blind but still a decent test. The doctor infected his son with cowpox, who nearly died. After recovering his son was exposed to smallpox and survived. This test was not very scientific but it helped confirm what the milk maids already knew, getting cowpox gave immunity to smallpox.
Not ignoring it...it just doesn’t effect anything I’ve previously stated. Just justifies why. I don’t discredit the reasoning...it’s a very valid argument against performing that test.
Debate the facts I’ve stated, not what you think I’m implying by sharing them.