Anonymous ID: 8330e2 QRB General #937: Dims Need Our Guns Cause... Edition June 10, 2022, 9:41 p.m. No.138491   🗄️.is 🔗kun   >>8539

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Anonymous ID: 8330e2 June 10, 2022, 9:44 p.m. No.138492   🗄️.is 🔗kun

Globals

New bakers always welcome

 

Notables

are not endorsements

 

#936

>>138324 The Supreme Court indicates that both Monday and Wednesday of next week will be opinion days-screencap

>>138325 @theNRL-Michigan news: America First candidate for MI Governor Ryan Kelley had his arraignment just now. He was released on his own personal recognizance bond. America First candidate for MI Attorney General Matt DePerno greeted him outside the courthouse following his release.

>>138325 @washtimes CPAC to launch Jan. 6 facts website to combat ‘propaganda’ washingtontimes.com

>>138333, >>138351, >>138358 BLS: CPI increased 1.0% in May; Core CPI increased 0.6%-the largest 12-month increase since the period ending December 1981

>>138340 Potato mobile filling station on dooty over LA-NATN20 USAF KC-135 tanker-Not even "up" yet and they are using the InterContinental Los Angeles Downtown as a base

>>138343 The Biden administration will announce today that CDC is lifting its requirement for travelers to test negative before entering the U.S., per a senior administration official

>>138345,>>138369 @chuckrossdc-The Department of Homeland Security coordinated with Twitter on its Disinformation Governance Board, docs show-Whistleblower Showing DHS Intent to Weaponize

>>138346 Ukrainian Nazis continue to shell their own civilians. Footage from the Kirovsky district in the Donetsk People’s Republic. (IntelSlava)

>>138348 Locals from the Kharkov region of Ukraine thank Russian military medics providing medical assistance to civilians

>>138350 No more waiting around for the politicians to solve thing.

>>138351, >>138352 @realDonaldTrump -Just out, really bad CPI - 8.6%. Worst number since December, 1981 and Mkts no likey

>>138356 @X22Report No Testing, No Pandemic

>>138357 Europe-Med Planefaggin'-Polish leave Zurich one of those ACs been there since 0530/Hungarians moving around, Greeks left Vilnius/Moroccans left Paris/Italians running ISR patterns south of Madrid/Turks left Libya

>>138363, >>138367 NOW - Obama: "We have to take steps to detoxify our discourse, particularly the scourge of 'disinformation, conspiracy theories, and hate' online." @disclosetv

>>138364 Chief of Space Operations Gen. John W. "Jay" Raymond on the activation of Space Training and Readiness Command. @Spaceforce

>>138366 Disney was just downgraded to a ‘Strong Sell’ by Zacks.

>>138370 Klaus Schwab caught bragging about control

>>138371 Viganò. Deep State and Deep Church, Biden and Bergoglio: Frontmen of an Eversionary Dome.

>>138372 Spanish AF AME4527 Falcon 900 departed Brussels this is Spanish Foreign Minister José AlbaresInt'l after 4h 45min on ground and AME4517Falcon 900 left Luxembourg-reminder NATO Mtg end of the month in Madrid and big sperg-a-thon planned

>>138373 @Navy "welcome"

>>138374 @Marines

>>138376 @ARMY Your entire body will be tested, mentally and physically.

>>138377, >>138381 French AF CTM1281 Falcon 7x departing JFK Int'l after a ground stop of about 60 minutes-this is a high level VIP transport-dropped off someone then wet to Dulles Int'l

>>138379 Soaring Dollar Is "Only Safe Haven" Left’ After Hot US Inflation-not AG or Au? kek

>>138380 Commodity chaos from Ukraine war sends Trafigura to record $2.7 billion profit-plus links to Trafigura/Glencore and Mark Rich aka Commodities King

>>138383, >>138385 Chinese government-linked hackers are exploiting software vulnerabilities in foreign computer networks, creating infrastructure used for stealing information through cyber intrusions-wut no C_A? kek

>>138387 GOP IN Rep Banks on Fox on 1/6 cmte hrng: Last night's hearing was a primetime dud. Nothing came out of it that we didn't know before

>>138390, >>138393 Small plane crashes in Oxnard, California strawberry field

>>138391, >>138398 Polish AF PLF101 Duda departed Bucharest after 6h 45min on the ground-inbound from Rome-B9 Summit Mtg back to Warsaw

>>138394, >>138397, >>138399 Project Dunbar: international settlements using multi-CBDCs and some non-paid analysis

>>138400, >>138426, >>138427, >>138437, >>138439 (BIS) put a $14 Quadrillion lean on the US Corporation on July 28th 2011-got these from a drop on 103118...it cost then $198.00 to 'file' it to-what a deal!!

>>138401 AF2 USAF C-32Akneepadsdeparted Los Angeles Int'l after arriving one week ago from Reno-this AC arrived at LAX yesterday as SAM271 and was the AC that Mark Milley used last week

>>138409 Navy satellite center disestablished; U.S. Space Force assumes command in historic ceremony

>>138414 Ima so surprised news and they say this every year no one manipulates currency: U.S. Treasury says no major trading partner, including China, manipulated its currency in 2021

>>138420, >>138421 Mkt Fag: Muh Inflation actually worse but din't "get" to 9% but you all already knew this and knew that-'springing' the bear trap-edition + NYFRB dailt Operations and not.../s manipulated Currency Operations

>>138428 Dr Naomi Wolf’s Legal Team is Bringing Civil Suits Against Pfizer for Racketeering

>>138432 BioClandestine pointed out on TG that the monkey pox that was released or discovered in Nigeria where there are 4 US biolabs @DanRich

>>138438 sum BOGEYs north from SoCal F5 and O7...o7

>>138434, >>138440, >>138443, >>138444 Who "ownz da Chiefs" (i.e.) Everything meme and some other info

>>138449 @epochtimes Sen. Tom Cotton called on Attorney General Merrick Garland to resign or face impeachment following inaction after protests at #SupremeCourt justices’ homes.

>>138450, >>138455 “We’re in technical recession but just don’t realize it,” said Michael Hartnett.

>>138467 Biden promised Bolsonaro U.S. would reconsider tariffs on Brazil steel

>>138469 SPAR12 and 16 USAF C-40Bs departed Los Angeles Int'l NE

>>138472 All that 'big talk' about QT and all they did was one operation since it "started" on June 1st (done on June 8th) and it was 30 year non-matured GinneMac so lied about that.

>>138481 SAM941 USAF C-40BState Dept ACdeparted Los Angeles Int'l after arriving yesterday in front of SPAR16 yesterday

>>138490 #936

 

#935

>>138165 Hungarian AF HUAF258 A319 on descent for Stockholm-Hungary issues FX benchmark bonds worth $3.8 billion, minister says

>>138170 Europe-Med. planefaggin'-some tankers refueling jets off se Sweden in the Baltic-usually don't see that

>>138171 SAM258 USAF G5 KAF AC of interdast Wendy Sherman Dept. Sec. of State in Manila

>>138175 BOXER41 USAF C-40B went to Chisinau, Moldova from it's JBA departure yesterday

>>138177 Euro Weakens, Fragmentation Fears Rise As Hawkish Lagarde Promises Bond Bailout and "signals" rate hike-good luck on that!

>>138180 Polish AF PLF101 President Duda departed Lisbon after arriving yesterday-heading to Rome right nao-taking his gheyness to Rome

>>138181 SAM224 USAF C-40B departed MacDill AFB (CENTCOM) and this is a WH NSO AC NE after arriving yesterday-it was in Smell A on Tuesday and not for long

>>138183 Brazilian AF BRS01 A319 Based Bolsanaro arriving at Los Angeles Int' lfrom a Miami Int'l refuel/ground stop

>>138185 planefaggin' Europe Update: Duda to Rome/German AF Economic 'climate' douche from Amman/Greek AF Health minister from Tel Aviv

>>138187, >>138199 @X22Report-It’s like it was planned to happen right before the fake J6 hearing

>>138188 @Spaceforce It’s all coming together.

>>138190, >>138205 Fed's Flow of Funds: Household Net Worth Decreased $0.55 Trillion in Q1

>>138191 @Navy Awesome.

>>138193 @chiefnerd-White House Unveils COVID Vaccination Plan For Children Under 5, Orders 10 Million Doses Under 5??? come on man!!!

>>138194 @jsolomonreports-Watchdog suit forces DOJ to release memo declining criminal prosecution of Ashli Babbitt's shooter

>>138196 Republican Sen. John Cornyn of Texas, one of the lead negotiators in the Senate’s bipartisan talks to address mass shootings, has officially ruled out raising the age requirement to purchase guns

>>138197 @Marines

>>138199 @Electionwiz-Michigan GOP Governor candidate arrested, home raided after attending Jan 6 rally

>>138202 @Airforce Tiger king.

>>138206, >>138209 MASSIVE #MIGRANT #CARAVAN HEADING TO U.S. Yes...it's this shit AGAIN!

>>138215 Stellar 30Y Auction Sees "Buyers" Emerge Ahead Of Friday's CPI

>>138216 Something smells bad in Michigan 5 of 6 Repubs dumped from Ballot-sigs forged

>>138220 @ArchiveAnon Q Drop #4441 2 year delta

>>138221 @mattwhitaker46-The current version of Federal Extreme Risk Protection Order Act is an obvious effort to rob law abiding citizens of their 2A rights

>>138225, >>138226, >>138228, >>138250 UK anons with mystery poster

>>138229 SENATOR JOSH HAWLEY "Whistleblower documents show coordination between the Disinformation Governance Board and Big Tech executives to track and monitor American citizens 'engaging in misinformation.'" (KAGBABE)

>>138230 got two CHEAT61 USAF C-130 Hercules up the east coast of FL-FakeX launch of an Egyptian Satellite yesterday from Cape Canaveral Space Force Station

>>138239 "2000 Mules" continues to make waves as members of European Parliament Marcel de Graaff and Dr. Nicolaus Fest discussed a recent screening of the film

>>138241 Cheney's Jan. 6 committee spotlight burns her in Wyoming primary Cheney is trailing her leading GOP primary rival, attorney Harriet Hageman by 28-56 percent

>>138243 PGA Tour suspends all players in Saudi-backed LIV Golf league

>>138244, >>138245 JoeBama Put The Gang Back Together Inside The DOJ – John Carlin Returns as Acting Deputy AG

>>138252 Myanmar Updates: Election Fraud Trial, Executions, Coups, and Color Revolution

>>138256 How a Belgian Aristocrat Under Investigation for Money Laundering Moved Millions Into Colombia

>>138257 Mortgage rates jump, reaching 5.23%

>>138259 Social Security benefits likely to climb by 8% next year, official says

>>138263, >>138264 Mkt Fag: SSDD "US Stocks Pare Drop" early wut a surprise!.../s but then LaGarde throws some cold water on it via the Rate Hike "signal"and intra-day "flake" issue(s) (H&S) Bear Trap-edition + NYFRB Ops Another record @ $2.185.214T

>>138269, >>138273 BOGEY07 US Navy F-18 from Fallon AFB, NV "Top Gun" just flew over LA Basin at about 570kts and heading SE-he went to Brown Field on the US/Mex border

>>138272 (You) X22 It’s What You Don’t See, Durham Is Not The Only Game In Town, Make America Great Again –

>>138274 @Banners4Freedom-New Banner Raised in Surfside, South Carolina! -Banner is located on the busy Myrtle Beach strip!

>>138275 SAM941 USAF C-40B State Dept AC and SPAR16 on ground at Los Angeles Int'l-screencap of SPAR6 on Taxi Live from LAX Live Plane Spotters y/t

>>138288 SAM258 USAF G5 KAF AC of Interdast departed Manila, P.IDep Sec. of State Wendy "it's a dude" Sherman

>>138294, >>138295, >>138299 JW taking peeps to 8kun from TS, guud on him

>>138296, >>138306 dig on second plane crash in Palo Verde area

>>138304, >>138305 Electric Ford F150 Sticker price $140,603.--

>>138311 JASDF JF001 777 departed Tokyo-Haneda Airport to SingaporeThis is Japanese PM Kishida injecting self into the Singapore meetings

>>138319 #935

 

Previously Collected Notables:

>>137616 #930, >>137709 #931, >>137795 #932, >>137968 #933, >>138152 #934

>>136829 #925, >>136994 #926, >>137179 #927, >>137380 #928, >>137490 #929

>>136002 #920, >>136128 #921, >>136388 #922, >>136567 #923, >>136828 #924

 

QRB notables archived here >>>/qrb/9528

Anonymous ID: 8330e2 June 11, 2022, 7:32 a.m. No.138517   🗄️.is 🔗kun   >>8523 >>8539 >>8626 >>8627

Tesla announces a plan for a three-in-one 'stock split'to make shares cheaper and more accessible - freeing up more cash for the Elon Musk-owned company: Larry Ellison, 77, is leaving the board

 

Elon Musk's company made the announcement in their latest SEC filing, published on Friday, and said the annual meeting will be held on August 4

 

Tesla announced they were issuing four billion new shares in a three-in-one 'stock split' - a scheme they first floated in March this year

 

The procedure, approved by the board but needing shareholder approval, increases the number of shares, without diluting the value

 

The effect is to make each individual share significantly cheaper, and attract new buyers and an injection of cash

 

Tesla's shares closed on Friday at a little over $696 per share, meaning that if the split were to happen today, its stock would be worth $232 a share

 

The company said the move was to 'reset the market price of our common stock so that our employees will have more flexibility in managing their equity'

 

Tesla in August 2020 announced a five-in-one stock split, and the share price jumped 80 percent on the news

 

June 10, 2022

 

"Tesla has informed shareholders that it intends to complete a three-in-one 'stock split', designed to increase the number of shares available and bring down their price.

 

The update was published on Friday, as part of their latest SEC filing, which also announced an August 4 date for the annual shareholder meeting, and said that billionaire software magnate Larry Ellison, 77, was stepping down from the board.

 

Under the proposal, which the board has approved and now needs shareholder agreement, a person owning one share will now own three, with each of those shares worth a third of the original one."

 

Tesla's shares closed on Friday at $696, meaning that if the stock split went into effect immediately, each share would be worth $232.

 

The company said the scheme was to benefit their employees, saying it was designed to 'reset the market price of our common stock so that our employees will have more flexibility in managing their equity'.

 

Analysts said that the move was likely intended to encourage more people to buy shares, and bring a wave of new cash into the company.

 

Tesla's last stock split was in August 2020, with a five-in-one move that forced the share price up 80 percent.

 

Alphabet, the parent company of Google, and Amazon have also announced stock splits earlier this year.

 

Sauce/moar: https://www.dailymail.co.uk/news/article-10905617/Tesla-announces-plan-three-one-stock-split-make-shares-cheaper-accessible.html

Anonymous ID: 8330e2 June 11, 2022, 7:35 a.m. No.138518   🗄️.is 🔗kun   >>8539 >>8626 >>8627

Three US Military Aircraft Crash In Southern California Within One Week

 

https://www.zerohedge.com/military/three-us-military-aircraft-crash-southern-california-within-one-week

Anonymous ID: 8330e2 June 11, 2022, 7:37 a.m. No.138519   🗄️.is 🔗kun   >>8525 >>8539 >>8626 >>8627

Tragic Kingdom: Disney Shares Close Under $100 for First Time in More than Two Years

 

10 Jun 2022

 

Shares of the Walt Disney Co. continued their free fall this week, dropping 9 percent to close Friday at $99.40 — the first time the stock has closed below $100 in more than two years.

 

Disney shares took a significant beating this week following a major shake-up in the company’s executive suites. On Thursday, CEO Bob Chapek unexpectedly fired his presumed successor, Peter Rice, a move that has stunned the entertainment industry and left Disney employees in a state of shock.

 

For the year, Disney shares are down a whopping 37 percent, making it the worst performer on the Dow Jones Industrial Average during the past 12 months.

 

The last time Disney stock closed below $100 was in April 2020.

 

https://www.breitbart.com/entertainment/2022/06/10/tragic-kingdom-disney-shares-close-under-100-for-first-time-in-more-than-two-years/

Anonymous ID: 8330e2 June 11, 2022, 7:39 a.m. No.138520   🗄️.is 🔗kun   >>8539 >>8626 >>8627

@Reuters

 

Russia and China opened a new cross-border bridge. The bridge links the Russian city of Blagoveshchensk to the Chinese city of Heihe across the Amur river https://reut.rs/3tuUVEp

 

https://twitter.com/Reuters/status/1535471890537582592

Anonymous ID: 8330e2 June 11, 2022, 7:45 a.m. No.138521   🗄️.is 🔗kun   >>8539 >>8626 >>8627

B.C. money laundering inquiry will release final report on Wednesday after hearing from 199 witnesses

 

Premier John Horgan appointed Cullen in May 2019 to lead the inquiry after several reports determined billions of dollars linked to organized crime and the drug trade had affected B.C.'s gaming sector and the real estate and luxury vehicle markets.

 

Jun 10, 2022

 

https://www.cbc.ca/news/canada/british-columbia/bc-money-laundering-inquiry-report-set-for-release-1.6485473

 

In his testimony, David Eby said that the money laundering problem in British Columbia was so notorious that it was known among international intelligence groups as “the Vancouver model”.

 

In this model, gamblers, usually from China, who do not have cash, take money from gangsters and deposit them into a casino – these are the proceeds of gang crime, often in amounts as high as hundreds of thousands of dollars. The gambler then transfers money from his Chinese bank account to a bank account under the control of the gang. The illicit cash he took from the gangsters is taken into the casino, a FINTRAC reporting form is completed, and the gambler is free to buy chips, gamble, and then, cash out.

 

A series of media reports in the past few weeks suggested that there was a clear relation between shady transactions, crime proceeds and the skyrocketing housing market around Vancouver and in the Lower Mainland, in particular.

 

Due to the high value of luxury cars and pleasure craft, these items are excellent for storing illegal cash and reintroducing it to the legitimate economy. It turns out that multiple sectors in British Columbia have been affected by money laundering activities. International crime gangs have been targeting Vancouver’s economy, flooding it with proceeds from drug sales and other criminal activity. According to Eby, this continued for many years and is probably happening right now. Whether authorities will be capable of breaking that cycle and clearing Canada’s reputation remains to be seen.

 

https://www.casinoreports.ca/2018/05/01/how-suspicious-transactions-in-british-columbia-casinos-turned-into-canadas-biggest-money-laundering-scandal/

 

Vancouver was the first place to experience the tidal wave of Chinese cash. Now the city is leading efforts to stop it.

 

The black coupe pulled up outside the Starlight Casino in a suburb of Vancouver. The driver got out, greeted a man in a red shirt, and pulled two bulging white plastic bags from the trunk. He led the way into an empty noodle shop next door, where he handed over the bags before returning to the car. The man in the red shirt took the bags into the casino, through a cavernous glass lobby with signs in English and Mandarin. At a cashier’s desk, he opened one of the bags to present his cargo: thousands of green Canadian $20 bills, bound into loose bricks with yellow plastic bands.

 

The cashier’s counting machine would need to run continuously for more than 10 minutes to riffle through all the notes, which came to more than C$250,000 ($192,000). Converted into chips that could be cashed out later, whether or not they’d been wagered at the tables, the money would be spendable anywhere in Canada, unimpeded by questions of provenance.

 

One academic terms the process “the Vancouver model”: a seamy mingling of clean and dirty cash in casinos, real estate, and luxury goods made possible by historic ties to China and by Canada’s lax record of fighting financial crime.

 

https://www.bloomberg.com/news/features/2018-10-20/vancouver-is-drowning-in-chinese-money

Anonymous ID: 8330e2 June 11, 2022, 7:47 a.m. No.138522   🗄️.is 🔗kun   >>8527 >>8539 >>8626 >>8627

Ayyy lmao

 

U.S. Naval Institute

 

@NavalInstitute

 

Since #UFOs are trending following NASA's announcement that it is launching a study of unidentified aerial phenomena, it is interesting to note that Ronald Reagan and Mikhail Gorbachev agreed in 1985 that the U.S. and Russia would unite to fight any hostile aliens.

 

https://twitter.com/NavalInstitute/status/1535390661448503299

Anonymous ID: 8330e2 June 11, 2022, 7:53 a.m. No.138524   🗄️.is 🔗kun   >>8539 >>8626 >>8627

https://rumble.com/v17uysw-the-great-reset-x-files-season-10-2016-prophecies-the-great-reset-agenda.html

 

@TrueGenFlynn

·

1d

 

The Great Reset versus The Great Reawakening- I’ll bet on Americans reawakening.

Anonymous ID: 8330e2 June 11, 2022, 7:58 a.m. No.138526   🗄️.is 🔗kun   >>8539 >>8626 >>8627

Reminder

 

Sept 14, 2018

 

The EU has passed Article 13, but Europe's meme war is far from over

 

The EU has passed Article 13, its controversial "meme-killing" law, with very few amendments, but copyright enthusiasts shouldn't get too chirpy.

 

It would require web giants to automatically filter copyrighted material — songs, images, videos — uploaded on their platforms, unless it has been specifically licensed.

 

https://www.wired.co.uk/article/eu-article-13-passed-meme-war

Anonymous ID: 8330e2 June 11, 2022, 8:41 a.m. No.138537   🗄️.is 🔗kun   >>8539 >>8626 >>8627

They're going after Q+ because Q is going after the HRC criminal cabal.

 

Witch Hunt = Hunting the criminal 'witch' Hillary Clinton, COUNTER-COUNTER-INTEL OP.

 

HRC approved Russia Hoax to usurp duly elected President. That's sedition at the least.

Anonymous ID: 8330e2 June 11, 2022, 9:34 a.m. No.138542   🗄️.is 🔗kun   >>8543 >>8545

all 25 grilled yo

holy moly, nearly as many as we do all day

really thankful you collect cause it's be too much I think and you betters at it anyhow

SFT'lous GOLD yo

Anonymous ID: 8330e2 June 11, 2022, 9:44 a.m. No.138548   🗄️.is 🔗kun   >>8555 >>8626 >>8627

@imglover

·

7m

 

Uvalde Police Chief Finally Speaks, Says He Didn’t Tell Anyone to Stand Down #GEORGEnews

redstate.com/

 

@imglover

·

7m

Replying to @imglover

 

Governors Forming Task Force to Address Mass Shootings #GEORGEnews

newsmax.com

Anonymous ID: 8330e2 June 11, 2022, 10:01 a.m. No.138554   🗄️.is 🔗kun   >>8626 >>8627

@stormypatriotjoe

·

1h

 

More and More “Breakthroughs”…

 

https://interestingengineering.com/new-molecule-kills-deadliest-cancer

 

 

Recently, a tiny group of people with rectal cancer saw their disease vanish after experimental treatment.

 

It was a very small trial done by doctors at New York's Memorial Sloan Kettering Cancer Center, wherein the patients took a drug called dostarlimab for six months. At the end of their trial, every single one of their tumors disappeared.

 

Now, in another breakthrough, a new compound synthesized by Dr. Jung-Mo Ahn, a University of Texas at Dallas researcher, has been found to kill a broad spectrum of hard-to-treat cancers, including triple-negative breast cancer, leaving healthy cells unscathed.

 

He exploited a weakness in cells that were hitherto not targeted by the other drugs.

 

The study, which was carried out in isolated cells, both in human cancer tissue and in human cancers grown in mice, was published in the journal Nature Cancer.

Only a few options for patients with triple-negative breast cancer

 

Ahn, a co-corresponding author of the study and a UT Dallas associate professor of chemistry and biochemistry in the School of Natural Sciences and Mathematics, has been working on small molecules that target protein-protein interactions in cells for more than a decade. Previously, he had developed potential therapeutic candidate compounds for treatment-resistant breast cancer and prostate cancer.

 

In his current research, Ahn and his colleagues tested a new compound he synthesized called ERX-41 for its effects on breast cancer cells - those that contained estrogen receptors (ERs) and those that do not.

 

Now, there are effective treatments for patients with ER-positive breast cancer, but only a few treatment options for patients with triple-negative breast cancer (TNBC) exist. It lacks receptors for estrogen, progesterone, and human epidermal growth factor 2. TNBC is known to affect women under 40 and has worse outcomes than other types of breast cancer.

 

"The ERX-41 compound did not kill healthy cells, but it wiped out tumor cells regardless of whether the cancer cells had estrogen receptors," Ahn said. "In fact, it killed the triple-negative breast cancer cells better than it killed the ER-positive cells.

 

"This was puzzling to us at the time. We knew it must be targeting something other than estrogen receptors in the TNBC cells, but we didn't know what that was."

Researcher

Dr. Jung-Mo Ahn, associate professor of chemistry and biochemistry at UT Dallas, synthesized a novel compound called ERX-41 that has shown promise in eliminating cancer cells. Source: UT Dallas

No adverse effects in healthy mice

 

Soon, the researchers discovered that ERX-41 binds to lysosomal acid lipase A (LIPA), a cellular protein. LIPA is found in a cell structure called the endoplasmic reticulum, an organelle that processes and folds proteins.

 

"For a tumor cell to grow quickly, it has to produce a lot of proteins, and this creates stress on the endoplasmic reticulum," Ahn said. "Cancer cells significantly overproduce LIPA, much more so than healthy cells. By binding to LIPA, ERX-41 jams the protein processing in the endoplasmic reticulum, which becomes bloated, leading to cell death."

 

The team tested the molecule in healthy mice and noted that there were no ill effects.

"It took us several years to chase down exactly which protein was being affected by ERX-41. That was the hard part. We chased many dead ends, but we did not give up," Ahn said.

 

"Triple-negative breast cancer is particularly insidious - it targets women at younger ages; it's aggressive, and it's treatment-resistant. I'm really glad we've discovered something that has the potential to make a significant difference for these patients," Ahn said.

Can defeat the deadliest cancer

 

The researchers then fed the compound to mice with human forms of cancerous tumors, and they got smaller.

 

The molecule also killed cancer cells in human tissue that were gathered from patients who had their tumors removed.

 

There's more.

 

They found that ERX-41 is effective against other cancer types with elevated endoplasmic reticulum stress, including hard-to-treat pancreatic and ovarian cancers and glioblastoma, the most 'aggressive and lethal primary brain cancer'.

 

To investigate the ERX-41 molecule, Ahn worked with collaborators, including co-corresponding authors Dr. Ganesh Raj, professor of urology and pharmacology at the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern Medical Center, as well as Dr. Ratna Vadlamudi, professor of obstetrics and gynecology at UT Health San Antonio. Dr. Tae-Kyung Lee, a former UTD research scientist in Ahn's Bio-Organic/Medicinal Chemistry Lab, was also involved in synthesizing the compound.

 

Ahn is a joint holder of patents issued and pending on ERX-41 and related compounds, which have been licensed to the Dallas-based startup EtiraRX, a company co-founded in 2018 by Ahn, Raj, and Vadlamudi. The company has announced that it plans to begin clinical trials of ERX-41 as early as the first quarter of 2023, which offers the hope of effective new treatments.

 

Abstract: Triple-negative breast cancer (TNBC) has a poor clinical outcome, due to a lack of actionable therapeutic targets. Herein we define lysosomal acid lipase A (LIPA) as a viable molecular target in TNBC and identify a stereospecific small molecule (ERX-41) that binds LIPA. ERX-41 induces endoplasmic reticulum (ER) stress resulting in cell death, and this effect is on target as evidenced by specific LIPA mutations providing resistance. Importantly, we demonstrate that ERX-41 activity is independent of LIPA lipase function but dependent on its ER localization. Mechanistically, ERX-41 binding of LIPA decreases expression of multiple ER-resident proteins involved in protein folding. This targeted vulnerability has a large therapeutic window, with no adverse effects either on normal mammary epithelial cells or in mice. Our study implicates a targeted strategy for solid tumors, including breast, brain, pancreatic and ovarian, whereby small, orally bioavailable molecules targeting LIPA block protein folding, induce ER stress and result in tumor cell death.

Anonymous ID: 8330e2 June 11, 2022, 10:07 a.m. No.138557   🗄️.is 🔗kun   >>8558 >>8626 >>8627

@wqnderwqman

·

2h

 

NEW 🇷🇺🇺🇸 The Russian Ambassador to the US says: "Russia was forced to take drastic measures and start a special operation in Ukraine because it was impossible to leave Donbass to be torn to pieces by neo-Nazis."

 

He stressed that "Kyiv carried out an undisguised genocide against the Russian-speaking population in eastern Ukraine." (IntelSlava)

Anonymous ID: 8330e2 June 11, 2022, 10:58 a.m. No.138565   🗄️.is 🔗kun   >>8570 >>8572

>>138563

couldn't remember the dates for those planes, drew a blank when typing

nose it was about the Rot's "inhereting" those patents, member that

put all your opines n stuffs in today

feels comfy with it all

likes the feed now, lots

mabbe cull a couple moar

they turnin on TS

not qool

Anonymous ID: 8330e2 June 11, 2022, 2:04 p.m. No.138575   🗄️.is 🔗kun

>>138573

sorry to have missed you UK

and get the hell out the cat door

kek

 

had two cats with a cat door like that, was on couch, laid out prolly from nappin, both cats came tearing through, hair standing straight up, tails straight up, then dog stuck it's head through the door, like your pic, kek, cats pounced on that dog's head like cray, wouldn't let him go either, his owner had to come and pull him out, his face was scratched all to hell

Anonymous ID: 8330e2 June 11, 2022, 2:29 p.m. No.138580   🗄️.is 🔗kun   >>8581

>>138579

noice nap, you"

raining all day here, to beat the band, again

kek

radar says no

double kek

not sure if it gonna hitz wakers or not, radar off, mabbe not so far north

idk

Anonymous ID: 8330e2 June 11, 2022, 2:42 p.m. No.138583   🗄️.is 🔗kun

>>138581

yeah, comin off the gulf, dip a bit south then head northerly but radar here is off a bit, looks like wakes already had em, not running tween us

kek